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Titolo:
CHRONIC ALCOHOLIZATION ALTERS THE EXPRESSION OF 5-HT1A AND 5-HT1B RECEPTOR SUBTYPES IN RAT-BRAIN
Autore:
NEVO I; LANGLOIS X; LAPORTE AM; KLEVEN M; KOEK W; LIMA L; MAUDHUIT C; MARTRES MP; HAMON M;
Indirizzi:
UNIV PARIS 06,INSERM,U288,91 BLVD HOP F-75734 PARIS 13 FRANCE CTR RECH PIERRE FABRE F-81106 CASTRES FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 281, anno: 1995,
pagine: 229 - 239
SICI:
0014-2999(1995)281:3<229:CAATEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFERRING P-RATS; ADRENERGIC-RECEPTORS; BINDING-SITES; ETHANOL; PREFERENCE; CORTICOSTERONE; ANTAGONIST; WITHDRAWAL; BUSPIRONE; DRINKING;
Keywords:
ALCOHOLIZATION; 5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); RECEPTOR; MESSENGER-RNA; BINDING; AUTORADIOGRAPHY; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
I. Nevo et al., "CHRONIC ALCOHOLIZATION ALTERS THE EXPRESSION OF 5-HT1A AND 5-HT1B RECEPTOR SUBTYPES IN RAT-BRAIN", European journal of pharmacology, 281(3), 1995, pp. 229-239

Abstract

The expression of central 5-HT1A and 5-HT1B receptors was studied in several brain areas of rats subjected to a 2-week period of chronic alcoholization, followed by 18 h withdrawal. Quantitative autoradiography indicated that the ethanol treatment provoked an increase (similar to + 30%) in the labeling by [H-3]8-hydroxy-2-(di-n-propylamino)tetralin ([H-3]8-OH-DPAT) and [H-3]N-[2-[4-(2-methoxyphenyl)- 1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide ([H-3]WAY-100635) of 5-HT1A autoreceptors in the dorsal raphe nucleus, accompanied by a concomitant decrease in the labeling of postsynaptic 5-HT1A receptors in thehippocampus (similar to - 20%), anterior (similar to - 30%) and posterior (similar to - 32%) cortices. These changes were associated with atendency toward an increase and decrease in 5-HT1A mRNA levels in theanterior raphe area and hippocampus, respectively, suggesting that the changes observed are due to modifications in 5-HT1A receptor proteinsynthesis. The autoradiographic labeling of 5-HT1B receptors by tonin-O-carboxymethylglycyl[I-125]iodotyrosinamide ([I-125]GTI) was found to increase ( + 55 %) in the globus pallidus of alcoholized rats. Interestingly, a significant increase (+ 57%) in S-HT1B receptor mRNA levels was observed in the striatum, which contains cell bodies of neurons projecting into the globus pallidus. These data suggest that altered sensitivity of chronically alcoholized rats to 5-HT1A and 5-HT1B receptor ligands may result from alcohol-induced changes in the transcription of the genes encoding these receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:40:00