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Titolo:
CELLULAR IMMUNE-RESPONSES IN THE PIG UTERUS DURING PREGNANCY
Autore:
BISCHOF RJ; BRANDON MR; LEE CS;
Indirizzi:
UNIV MELBOURNE,SCH VET SCI,CTR ANIM BIOTECHNOL,DEPT ANAT & CELL BIOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of reproductive immunology
fascicolo: 2, volume: 29, anno: 1995,
pagine: 161 - 178
SICI:
0165-0378(1995)29:2<161:CIITPU>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-T; INTERLEUKIN-2 RECEPTOR; MONOCLONAL-ANTIBODIES; GRANULAR LYMPHOCYTES; IMPLANTATION; CELLS; TROPHECTODERM; MACROPHAGES; POPULATION; SUPPRESSOR;
Keywords:
PIG; PREGNANCY; UTERUS; LOCAL IMMUNE SYSTEM; ENDOMETRIAL LEUKOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Bischof et al., "CELLULAR IMMUNE-RESPONSES IN THE PIG UTERUS DURING PREGNANCY", Journal of reproductive immunology, 29(2), 1995, pp. 161-178

Abstract

In pigs, little is known about the role of the uterine immune system during pregnancy. Immunohistochemical studies were conducted using a panel of monoclonal antibodies to pig leukocytes on uterine tissues taken from gilts after fertile mating and at different stages of pregnancy. Acute inflammation in the endometrium in response to fertile matingwhich included marked changes in the tissue and immune cell components of the endometrium was observed. Throughout pregnancy the pig uteruscontained a substantial population of leukocytes. MHC class II staining was prominent in the endometrium at all stages examined and included macrophages, dendritic and fibroblast-like cells, lymphocytes and the endothelial lining of many uterine blood vessels. The majority of lymphoid cells were CD2(+), indicating the prevalence of T cells. In early pregnancy specific changes were seen in the tissue distribution of uterine immune cells. Following placentation distinct cellular changesin the local immune cell environment of the uterus were also observeddespite the non-invasive nature of the pig placenta. There appears tobe suppression and activation of various immune cell components in the uteri of pregnant pigs. This phenomenon is presumably in response tofoetal or trophoblast antigens, suggesting that the local immune system is involved in the uterine response to pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:53:26