Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INDUCTION OF CYCLOOXYGENASE-2 IN HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS BY LYSOPHOSPHATIDYLCHOLINE
Autore:
ZEMBOWICZ A; JONES SL; WU KK;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,VASC BIOL RES CTR HOUSTON TX 77030 UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DIV HEMATOL HOUSTON TX 77030
Titolo Testata:
The Journal of clinical investigation
fascicolo: 3, volume: 96, anno: 1995,
pagine: 1688 - 1692
SICI:
0021-9738(1995)96:3<1688:IOCIHU>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN ENDOPEROXIDE SYNTHASE; LOW-DENSITY LIPOPROTEIN; PROTEIN-KINASE-C; G/H SYNTHASE; INCREASED PROSTACYCLIN; COMPLEMENTARY-DNA; POTENTIAL ROLE; CULTURED HUMAN; PHORBOL ESTER; ATHEROSCLEROSIS;
Keywords:
NITRIC OXIDE; PROSTACYCLIN; ENDOTHELIUM; ATHEROSCLEROSIS; LOW DENSITY LIPOPROTEINS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
A. Zembowicz et al., "INDUCTION OF CYCLOOXYGENASE-2 IN HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS BY LYSOPHOSPHATIDYLCHOLINE", The Journal of clinical investigation, 96(3), 1995, pp. 1688-1692

Abstract

Lysophosphatidylcholine (lysoPC), a component of atherogenic lipoproteins and atherosclerotic lesions, has been recently suggested to play a role in atherogenesis, LysoPC is known to induce several endothelialgenes involved in leukocyte recruitment, mitogenesis, and inflammation, Cyclooxygenases (prostaglandin H-2 synthases) are rate-limiting enzymes involved in the endothelial synthesis of prostacyclin, an antiplatelet, vasorelaxant, and vasoprotective molecule, We investigated the effect of lysoPC on the endothelial expression of cyclooxygenases. Ourresults demonstrate that, in cultured human umbilical vein endothelial cells, lysoPC induces cyclooxygenase-2 mRNA and protein levels, Increased expression of cyclooxygenase-2 is accompanied by the enhancementof both basal- and calcium ionophore A23187-induced synthesis of prostacyclin. Nuclear runoff experiments demonstrated an increased rate oftranscription of the cyclooxygenase-2 gene by lysoPC, In contrast, lysoPC did not affect the expression of constitutive cyclooxygenase-1, Our results suggest that the induction of endothelial cyclooxygenase-2 by lysoPC may be an important vasoprotective mechanism that limits progression of atherosclerotic lesions and promotes their regression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:10:54