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Titolo:
ADVANCED GLYCATION ENDPRODUCTS INTERACTING WITH THEIR ENDOTHELIAL RECEPTOR INDUCE EXPRESSION OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN CULTURED HUMAN ENDOTHELIAL-CELLS AND IN MICE - A POTENTIAL MECHANISM FOR THE ACCELERATED VASCULOPATHY OF DIABETES
Autore:
SCHMIDT AM; HORI O; CHEN JX; LI JF; CRANDALL J; ZHANG JH; CAO R; YAN SD; BRETT J; STERN D;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,DEPT MED,P&S 11-518,630 W 168TH ST NEWYORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PHYSIOL NEW YORK NY 10032
Titolo Testata:
The Journal of clinical investigation
fascicolo: 3, volume: 96, anno: 1995,
pagine: 1395 - 1403
SICI:
0021-9738(1995)96:3<1395:AGEIWT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSYLATION END-PRODUCTS; GLUCOSE-MODIFIED PROTEINS; CORONARY-ARTERY DISEASE; BINDING-PROTEINS; GROWTH-FACTOR; SURFACE; TISSUE; ATHEROGENESIS; MELLITUS; COLLAGEN;
Keywords:
HYPERGLYCEMIA; ATHEROSCLEROSIS; ADHESION MOLECULE; ENDOTHELIUM; OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Schmidt et al., "ADVANCED GLYCATION ENDPRODUCTS INTERACTING WITH THEIR ENDOTHELIAL RECEPTOR INDUCE EXPRESSION OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN CULTURED HUMAN ENDOTHELIAL-CELLS AND IN MICE - A POTENTIAL MECHANISM FOR THE ACCELERATED VASCULOPATHY OF DIABETES", The Journal of clinical investigation, 96(3), 1995, pp. 1395-1403

Abstract

Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. In view of the acceleratedvascular disease observed in patients with diabetes, and the enhancedexpression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE), Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts, The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction, Electrophoretic mobility shift assays on nuclear extracts from AGE-treated ECs showed induction of specific DNA binding activity for NF-LB in the VCAM-1 promoter, which was blocked by anti-RAGE IgG or N-acetylcysteine. Soluble VCAM-1 antigen was elevated in human diabetic plasma, These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:02:37