Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TRANS-FATTY-ACIDS AND CORONARY HEART-DISEASE RISK
Autore:
KRISETHERTON PM;
Indirizzi:
INT LIFE SCI INST,1126 16TH ST NW WASHINGTON DC 20036 PENN STATE UNIV,DEPT NUTR UNIVERSITY PK PA 16802 COLUMBIA UNIV,ST LUKES ROOSEVELT HOSP,COLL PHYS & SURG,OBES RES CTR NEW YORK NY 10025 UNIV TEXAS,SOUTHWESTERN MED CTR,DEPT INTERNAL MED,CTR HUMAN NUTR DALLAS TX 75235 USDA ARS,NATL CTR AGR UTILIZAT RES PEORIA IL 61604 UNIV LOWELL,DEPT CLIN SCI LOWELL MA 01854
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 3, volume: 62, anno: 1995,
pagine: 651 - 708
SICI:
0002-9165(1995)62:3<651:TACHR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; SUBCUTANEOUS ADIPOSE-TISSUE; ESTER TRANSFER PROTEIN; UNITED-STATES DIET; MATURE HUMAN-MILK; ATE LESS FAT; LINOLEIC-ACID; SERUM-LIPIDS; PLASMA-CHOLESTEROL; HYDROGENATED OILS;
Keywords:
TRANS (ISOMETRIC) FATTY ACIDS INTAKE; PARTIALLY HYDROGENATED VEGETABLE OILS; ATHEROSCLEROSIS; EPIDEMIOLOGY; CORONARY HEART DISEASE; LIPOPROTEIN; PLASMA LDL-CHOLESTEROL REGULATION; HUMAN STUDIES; ANIMAL STUDIES; BIOCHEMISTRY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
226
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Krisetherton, "TRANS-FATTY-ACIDS AND CORONARY HEART-DISEASE RISK", The American journal of clinical nutrition, 62(3), 1995, pp. 651-708

Abstract

This review critically evaluates the scientific data on trans fatty acids and coronary heart disease (CHD) risk. Trans fatty acids are present in a variety of foods but they contribute only 4-12% of total dietary fat intake (2-4% of total energy intake) in the United States. Thephysical properties of trans fatty acids are intermediate between cisand saturated fatty acids, but a trans double bond is chemically lessreactive than a cis double bond. Biochemical data indicate that transfatty acids are subject to the same metabolic control mechanisms thatregulate the metabolism of saturated and cis-isomeric fatty acids. Equivocal results have been reported in observational studies of trans fatty acid intake and CHD because of numerous methodologic limitations,including the difficulties inherent in quantifying trans fatty acid intake. Studies in hamsters indicate that trans fatty acids have a neutral effect on low-density-lipoprotein (LDL)-receptor activity, LDL-cholesterol production rate, and plasma LDL-cholesterol concentration. Other animal studies show no differences in atherosclerosis incidence orseverity between diets containing hydrogenated and native vegetable oils. In clinical studies partially hydrogenated oils lower total and LDL-cholesterol concentrations when substituted for animal or vegetablefats rich in saturates but raise total and LDL-cholesterol concentrations when substituted for the unhydrogenated native oil. The effects of trans fatty acids on high-density lipoprotein cholesterol and lipoprotein(a) concentrations are unclear because of limited and conflictingclinical data. Data supporting a relation between trans fatty acid intake and CHD risk are equivocal compared with extensive data from studies in animals and humans linking saturated fat intake to CHD. Additional research is needed to resolve questions about the independent effects of trans fatty acids on plasma lipoproteins and their mechanisms of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:48:00