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Titolo:
LACK OF VACUOLAR PROTON ATPASE ASSOCIATION WITH THE CYTOSKELETON IN OSTEOCLASTS OF OSTEOSCLEROTIC (OC OC) MICE/
Autore:
NAKAMURA I; TAKAHASHI N; UDAGAWA N; MORIYAMA Y; KUROKAWA T; JIMI E; SASAKI T; SUDA T;
Indirizzi:
SHOWA UNIV,SCH DENT,DEPT BIOCHEM,SHINAGAWA KU,1-5-8 HATANODAI TOKYO 142 JAPAN SHOWA UNIV,SCH DENT,DEPT BIOCHEM,SHINAGAWA KU TOKYO 142 JAPAN SHOWA UNIV,SCH DENT,DEPT ORAL ANAT,SHINAGAWA KU TOKYO 142 JAPAN HIROSHIMA UNIV,GRAD SCH GENE SCI,DIV MOL BIOL MUKAISHIMA HIROSHIMA 722 JAPAN UNIV TOKYO,SCH MED,DEPT ORTHOPED,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 401, anno: 1997,
pagine: 207 - 212
SICI:
0014-5793(1997)401:2-3<207:LOVPAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-RESORPTION; H+-ATPASE; OSTEOBLASTIC CELLS; MOUSE; GENE; MUTATIONS; PUMP;
Keywords:
OSTEOSCLEROSIS; OC/OC; VACUOLAR PROTON ATPASE; RUFFLED BORDER; RENAL PROXIMAL CONVOLUTED TUBULE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
I. Nakamura et al., "LACK OF VACUOLAR PROTON ATPASE ASSOCIATION WITH THE CYTOSKELETON IN OSTEOCLASTS OF OSTEOSCLEROTIC (OC OC) MICE/", FEBS letters, 401(2-3), 1997, pp. 207-212

Abstract

We examined the pathogenetic mechanism underlying the lack of bone resorption in osteosclerotic ocloc mice, An immunoelectron microscopic analysis revealed that in the osteoclasts of these mice, no ruffled borders formed, and that vacuolar H+-ATPase (V-ATPase) was present throughout the cytoplasm but not on the apical membranes, The activity of V-ATPase in ocloc mice was similar to that in normal mice, In normal spleen cell-derived osteoclast-like cells (OCLs), immunoreactivity for V-ATPase was detected in association with Triton X-100-insoluble cellular structure, but not in ocloc spleen cell-derived OCLs. Moreover, in renal proximal convoluted tubules of ocloc mice, the basal striation did not form. These results suggest that osteosclerosis in ocloc mice ispossibly due to the dissociation of V-ATPase and cytoskeleton in osteoclasts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:51:20