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Titolo:
A TRANSFORMED MURINE MYOCARDIAL VASCULAR ENDOTHELIAL-CELL CLONE - CHARACTERIZATION OF CELLS IN-VITRO AND OF TUMORS DERIVED FROM THE CLONE IN-SITU
Autore:
PLENDL J; SINOWATZ F; AUERBACH R;
Indirizzi:
UNIV MUNICH,INST VET ANAT,VET STR 13 D-80539 MUNICH GERMANY UNIV WISCONSIN,CTR DEV BIOL MADISON WI 53706
Titolo Testata:
Virchows Archiv
fascicolo: 6, volume: 426, anno: 1995,
pagine: 619 - 628
SICI:
0945-6317(1995)426:6<619:ATMMVE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOLICHOS-BIFLORUS AGGLUTININ; GRIFFONIA SIMPLICIFOLIA-I; EPITHELIOID HEMANGIOENDOTHELIOMA; MICROVASCULAR ENDOTHELIUM; LYCOPERSICON-ESCULENTUM; ORGAN-SPECIFICITY; LECTIN; BINDING; LINE; TUMORS;
Keywords:
EPITHELIOID HEMANGIOENDOTHELIOMA; HEART NEOPLASMS; CELL LINE; FLOW CYTOMETRY; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
J. Plendl et al., "A TRANSFORMED MURINE MYOCARDIAL VASCULAR ENDOTHELIAL-CELL CLONE - CHARACTERIZATION OF CELLS IN-VITRO AND OF TUMORS DERIVED FROM THE CLONE IN-SITU", Virchows Archiv, 426(6), 1995, pp. 619-628

Abstract

In the course of maintaining a cloned murine myocardium-derived endothelial cell line (mouse heart endothelial cell clone 5; MHEC5) a spontaneously transformed variant has been identified (clone MHEC5-T). On injection into histocompatible mice, clone MHEC5-T uniformly generated epithelioid haemangioendotheliomas. Clone MHEC5-T underwent significant additional alterations in addition to the acquisition of tumour-forming potential ill vivo along with the diagnostic col-relate of loss ofcellular contact inhibition in vitro, Whereas the transformed cells maintained lectin-binding properties characteristic of endothelial cells, they lost the cell surface receptor(s) for acetylated low density lipoprotein and no longer bound antibodies to either angiotensin converting enzyme or von Willebrand factor-associated antigen, Vascular celladhesion molecule-1 (VCAM-1), expressed constitutively on the parent clone, was clown regulated in the transformed cell line. The transformed cells acquired immunoreactivity to antibodies directed against cytokeratin, and they showed a markedly increased response to migration-inducing factors in vitro. The cell line described in this report demonstrates that the in vitro transformation of myocardium-derived endothelial cells can lead through transitional stages of differentiation to anew stable phenotype characterized by endothelial - to - epithelioid transition, The study of MHEC5-T cells, in addition to providing insight into the biology of cardiac neoplasms, may help to elucidate regulatory mechanisms involved in endothelial cell activation, transition and transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:23:54