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Titolo:
ANTIVIRAL EFFECTS OF FOSCARNET AND GANCICLOVIR THERAPY ON HUMAN-IMMUNODEFICIENCY-VIRUS P24 ANTIGEN IN PATIENTS WITH AIDS AND CYTOMEGALOVIRUS RETINITIS
Autore:
QUINN TC; JABS DA; HOLBROOK JT; HARDY WD; POLSKY B; LEWIS RA; CLOGSTON P; FAINSTEIN V; GROSS R; SAMO T; TUTTLE C; APUZZO L; BARTLETT J; DUNN JP; ELDRED L; FEINBERG J; FLYNN T; KING R; BARRON B; GREENSPAN D; LECOUNT C; PEYMAN G; FRANKLIN R; HEINEMANN M; SQUIRES K; WISECAMPBELL S; FRIEDMAN AH; CHEUNG TW; JUSTIN N; TEICH SA; SACKS H; SEVERIN C; FRIEDBERG DN; ADDESSI A; DIETERICH D; LAFLEUR F; WEINBERG D; JAMPOL L; MURPHY R; NAUGHTON K; HENDERLY D; HOLLAND GN; CHAFEY S; FALL H; KIMBRELL C; MACARTHUR LJ; FREEMAN WR; MEIXNERT L; PETERSON TJ; QUICENO JI; RICKMAN L; SIMANELLO MA; SPECTOR S; ODONNELL J; HOFFMAN J; IRVINE A; JACOBSON M; LARSON J; SEIFF S; WARNER L; DAVIS J; CHUANG E; ESPINAL M; MENDEZ P; CHEESEMAN SH; GITTINGER J; HAUBRICH R; KACHADOORIAN H; TOLSON K; BROWNBELLAMY J; KLEMM AC; MARKOWITZ JA; MEINERT CL; AMENDLIBERCCI A; COLESON L; COLLINS KL; COLLISON BJ; DODGE J; DONITHAN M; EWING C; FINK N; GERCZAK C; ISAACSON MR; KAPLANGILIPIN A; HUFFMAN R; LEVINE CR; NOWAKOWSKI DJ; SMITH M; TONASCIA J; VANNATTA ML; AGRESSEGAL M; ARMSTRONG J; BROTHERS R; HUBBARD L; HURLBURT D; MAGLI Y; MINER K; THOMAS S; VANDERHOOFYOUNG M; STEWART G; HUGHES R; LEEF J; PALMER S; MOWERY R; ELLENBERG S; KORVICK J; DAVIS MD; CLARK T; MERIN L; SATTLER F; JORDAN C; MILLS J; BROWN BW; CONWAY B; GRIZZLE J; NUSSENBLATT R; PHAIR J; SMITH H; KLINE R; MOSS M; CARELLA A;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,550 BLDG,SUITE 700 BALTIMORE MD 21205 NIAID BALTIMORE MD 21205 UNIV CALIF LOS ANGELES LOS ANGELES CA 90024 CORNELL MED CTR NEW YORK NY 00000 BAYLOR COLL MED,CULLEN EYE INST HOUSTON TX 77030 LOUISIANA STATE UNIV,MED CTR NEW ORLEANS LA 00000 CORNELL UNIV,NEW YORK HOSP,MED CTR NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021 MT SINAI SCH MED NEW YORK NY 00000 NYU,MED CTR NEW YORK NY 00000 NORTHWESTERN UNIV CHICAGO IL 00000 UNIV CALIF SAN DIEGO SAN DIEGO CA 92103 USN HOSP BETHESDA MD 20814 UNIV CALIF SAN FRANCISCO SAN FRANCISCO CA 94143 UNIV MIAMI,SCH MED MIAMI FL 00000 UNIV MASSACHUSETTS,MED CTR WORCESTER MA 00000 JOHNS HOPKINS UNIV,CTR COORDINATOR,SCH HYG & PUBL HLTH BALTIMORE MD 21218 UNIV WISCONSIN,FUNDUS PHOTOGRAPH READING CTR MADISON WI 00000 ERC BIOSERV CORP,CTR DRUG DISTRIBUT ROCKVILLE MD 00000 BIOMED RES INST,SERUM & CMV CULTURE REPOSITORY ROCKVILLE MD 20852 NEI BETHESDA MD 00000 NIAID BETHESDA MD 00000
Titolo Testata:
The Journal of infectious diseases
fascicolo: 3, volume: 172, anno: 1995,
pagine: 613 - 621
SICI:
0022-1899(1995)172:3<613:AEOFAG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-DEFICIENCY-SYNDROME; REPLICATION INVITRO; ACID DISSOCIATION; PHOSPHONOFORMATE FOSCARNET; CONTROLLED TRIAL; ZIDOVUDINE; INFECTION; DISEASE; TYPE-1; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
T.C. Quinn et al., "ANTIVIRAL EFFECTS OF FOSCARNET AND GANCICLOVIR THERAPY ON HUMAN-IMMUNODEFICIENCY-VIRUS P24 ANTIGEN IN PATIENTS WITH AIDS AND CYTOMEGALOVIRUS RETINITIS", The Journal of infectious diseases, 172(3), 1995, pp. 613-621

Abstract

To examine whether the prolonged survival seen in patients treated with foscarnet compared with those treated with ganciclovir was due to adirect effect on human immunodeficiency virus (HIV) replication, HIV p24 antigen was measured. Of 71 receiving foscarnet, 54% were p24 antigen-positive at enrollment (vs. 44% of 79 receiving ganciclovir). By immune complex-dissociated (ICD) p24 antigen analysis, 87% and 78%, respectively, were positive. After 1 month of treatment, there was a significant decline in standard (mean decline, 10.1 pg/mL) and ICD (mean, 39.6 pg/mL) p24 antigen in both groups (P = .0001). Mortality was greater in those who were ICD p24 antigen-positive than in those -negativeat baseline (P = .03) and in subjects with an increase in ICD p24 antigen than in those with a decline (P = .09). Thus, each drug had a suppressive effect on circulating p24 antigen, which was predictive of improved survival. The inhibitory effect on CMV replication may have a beneficial effect on limiting HIV replication.

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Documento generato il 02/07/20 alle ore 18:53:25