Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MUTATION ANALYSIS OF BRCA1 AND BRCA2 IN A MALE BREAST-CANCER POPULATION
Autore:
FRIEDMAN LS; GAYTHER SA; KUROSAKI T; GORDON D; NOBLE B; CASEY G; PONDER BAJ; ANTONCULVER H;
Indirizzi:
UNIV CAMBRIDGE,ADDENBROOKES HOSP,CRC,HUMAN CANC GENET RES GRP,BOX 238,LEVEL 3 LABS BLOCK CAMBRIDGE CB2 2QQ ENGLAND UNIV CALIF IRVINE,DEPT MED,DIV EPIDEMIOL IRVINE CA 92717 CLEVELAND CLIN RES INST CLEVELAND OH 00000
Titolo Testata:
American journal of human genetics
fascicolo: 2, volume: 60, anno: 1997,
pagine: 313 - 319
SICI:
0002-9297(1997)60:2<313:MAOBAB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN-CANCER; SUSCEPTIBILITY GENE; FAMILIAL BREAST; LINKAGE; RISK; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Friedman et al., "MUTATION ANALYSIS OF BRCA1 AND BRCA2 IN A MALE BREAST-CANCER POPULATION", American journal of human genetics, 60(2), 1997, pp. 313-319

Abstract

A population-based series of 54 male breast cancer cases from Southern California were analyzed for germ-line mutations in the inherited breast/ovarian cancer genes, BRCA1 and BRCA2. Nine (17%) of the patientshad a family history of breast and/or ovarian cancer in at least one first-degree relative. A further seven (13%) of the patients reported breast/ovarian cancer in at least one second-degree relative and in nofirst-degree relatives. No germ-line BRCA1 mutations were found. Two male breast cancer patients (4% of the total) were found to carry novel truncating mutations in the BRCA2 gene. Only one of the two male breast cancer patients carrying a BRCA2 mutation had a family history of cancer, with one case of ovarian cancer in a first-degree relative. The remaining eight cases (89%) of male breast cancer with a family history of breast/ovarian cancer in first-degree relatives remain unaccounted for by mutations in either the BRCA1 gene or the BRCA2 gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:21:59