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Titolo:
MALIGNANT POTENTIAL IN INTESTINAL JUVENILE POLYPOSIS SYNDROMES
Autore:
COBURN MC; PRICOLO VE; DELUCA FG; BLAND KI;
Indirizzi:
RHODE ISL HOSP,DEPT SURG,593 EDDY ST PROVIDENCE RI 02902 BROWN UNIV,SCH MED,DEPT SURG PROVIDENCE RI 02912
Titolo Testata:
Annals of surgical oncology
fascicolo: 5, volume: 2, anno: 1995,
pagine: 386 - 391
SICI:
1068-9265(1995)2:5<386:MPIIJP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL POLYPOSIS; COLONIC POLYPOSIS; MIXED JUVENILE; COLI; CARCINOMA; MANAGEMENT; ADENOMAS; CANCER;
Keywords:
INTESTINAL POLYPS; JUVENILE POLYPOSIS SYNDROMES; GASTROINTESTINAL CARCINOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Coburn et al., "MALIGNANT POTENTIAL IN INTESTINAL JUVENILE POLYPOSIS SYNDROMES", Annals of surgical oncology, 2(5), 1995, pp. 386-391

Abstract

Background: Unlike familial polyposis coli, where the premalignant nature of adenomatous polyps is well established, the cancer risk in juvenile polyposis has generally been considered not increased. Methods: This study reviews all cases of juvenile polyposis reported in the English language to date to assess the occurrence and prognosis of carcinoma in the gastrointestinal tract. Results: A total of 218 patients met the inclusion criteria. Mean age at diagnosis was 18.5 years (range:9 months to 67 years). No gender preference was identified. The most common presenting symptom was chronic anemia, followed by acute gastrointestinal bleeding, rectal prolapse of polyp, protein-losing enteropathy, and intussusception. A family history of juvenile polyposis couldbe established in similar to 50% of patients, and associated congenital malformations were detected in 15%. Ninety-nine patients underwent 138 gastrointestinal operations: 121 colorectal, 12 gastric, and 5 small intestinal procedures. The development of a gastrointestinal carcinoma was reported in 36 cases (17%). Mean age at diagnosis of carcinomawas 35.5 years (range: 4-60 years). Most malignancies were located inthe distal colon and rectum, with only one case of gastric and one case of duodenal carcinoma. Tumor stage at diagnosis was usually advanced, with poor survival figures. Conclusions: This study shows that juvenile polyposis syndromes carry a more significant risk of carcinoma than generally appreciated. Therefore, more intense endoscopic surveillance may be warranted, and definitive surgical options should often be considered in these syndromes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:11:21