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Titolo:
STUDIES ON THE ACTIVATION MECHANISMS OF GUANYLYL CYCLASE BY SEROTONIN, PROBABLY THROUGH A NOVEL SUBTYPE OF SEROTONIN RECEPTOR (5-HTGC)
Autore:
TOHDA M; IMAIZUMI R; SEKIYA A; ITOH N; NOMURA Y;
Indirizzi:
HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KITA KU SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KITA KU SAPPORO HOKKAIDO 060 JAPAN TOYAMA MED & PHARMACEUT UNIV,ORIENTAL MED RES INST,DEPT NEUROSCI TOYAMA 93001 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 8, volume: 18, anno: 1995,
pagine: 1072 - 1075
SICI:
0918-6158(1995)18:8<1072:SOTAMO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN MESSENGER-RNA; CYCLIC-GMP; NG108-15 CELLS; RAT LUNG; PRECURSOR; RESPONSES; ARGININE; LEVEL;
Keywords:
SEROTONIN; GUANYLYL CYCLASE; NEURON; NATRIURETIC PEPTIDE; GLIA; NG108-15;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M. Tohda et al., "STUDIES ON THE ACTIVATION MECHANISMS OF GUANYLYL CYCLASE BY SEROTONIN, PROBABLY THROUGH A NOVEL SUBTYPE OF SEROTONIN RECEPTOR (5-HTGC)", Biological & pharmaceutical bulletin, 18(8), 1995, pp. 1072-1075

Abstract

Characterization of the serotonin-induced increase in guanosine 3',5'-cyclic monophosphate (cyclic GMP) was investigated and compared with that induced by atrial natriuretic peptide (ANP) in NG108-15 cells. The cyclic GMP formed by serotonin or ANP was transported in a similar manner to the extracellular medium, although the cyclic GMP formed by bradykinin was not. Serotonin and ANP raised cyclic CMP additively. Serotonin-induced cyclic GMP formation was completely inhibited by pretreatment with 100 nM 12-o-tetradecanoylphorbol 13-acetate (TPA), although that induced by ANP was only partialy inhibited and the effects wereblocked by pretreatment with staurosporin. In membrane preparations, ANP stimulated cyclic GMP formation in the presence of ATP, but serotonin did not. Serotonin-stimulated cyclic GMP formation was found to occur in neuroblastoma N18TG-2, but not in glioma C6Bu-1. These results suggest that a novel subtype of serotonin receptors (5-HTGC) which stimulates membrane-bound guanylyl cyclase, different from that stimulated by natriuretic peptide, may exist especially in neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:12:44