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Titolo:
MYOCARDIAL KINETICS OF A PUTATIVE HYPOXIC TISSUE MARKER, TC-99M-LABELED NITROIMIDAZOLE (BMS-181321), AFTER REGIONAL ISCHEMIA AND REPERFUSION
Autore:
STONE CK; MULNIX T; NICKLES RJ; RENSTROM B; NELLIS SH; LIEDTKE AJ; NUNN AD; KUCZYNSKI BL; RUMSEY WL;
Indirizzi:
UNIV WISCONSIN,CTR CLIN SCI,DEPT MED CARDIOL,CARDIOVASC RES LAB,CARDIOL SECT,600 HIGHLAND AVE MADISON WI 53792 UNIV WISCONSIN,DEPT MED PHYS MADISON WI 53792 UNIV WISCONSIN,DEPT RADIOL NUCL MED MADISON WI 53792 BRACCO RES USA PRINCETON NJ 00000
Titolo Testata:
Circulation
fascicolo: 5, volume: 92, anno: 1995,
pagine: 1246 - 1253
SICI:
0009-7322(1995)92:5<1246:MKOAPH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIC OXIDATION; FLUOROMISONIDAZOLE; IDENTIFICATION; INFARCTION; GLUCOSE;
Keywords:
TECHNETIUM; ISOTOPES; NITROIMIDAZOLE; MYOCARDIUM; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
C.K. Stone et al., "MYOCARDIAL KINETICS OF A PUTATIVE HYPOXIC TISSUE MARKER, TC-99M-LABELED NITROIMIDAZOLE (BMS-181321), AFTER REGIONAL ISCHEMIA AND REPERFUSION", Circulation, 92(5), 1995, pp. 1246-1253

Abstract

Background A new nitroimidazole complex, Tc-99m-propylene amine oxime-1,2-nitroimidazole (BMS-181321), has been developed to allow the positive imaging of hypoxic myocardium by standard gamma camera techniques. Methods and Results To determine the myocardial kinetics of BMS-181321 during myocardial ischemia and reperfusion, seven open-chest swine were prepared according to a model of extracorporeal coronary perfusion in which left ventricular wall thickening (percent end-diastolic thickness) and substrate use in the left anterior descending (LAD) region([C-14]palmitate and [H-3]glucose infusions) were determined. Measurements were obtained at baseline, during 40 minutes of ischemia produced by reducing flow in the LAD distribution by 60%, and during 70 minutes of reperfusion. Three aerobic control hearts were also studied in which LAD blood flow was not reduced. Regional coronary circulation wasfurther assessed in all hearts by use of radiolabeled microspheres injected during ischemia. BMS-181321 (20 to 30 mCi) was injected after 30 minutes of ischemia, and its myocardial uptake was assessed by dynamic planar gamma imaging. Ischemia was associated with declines in fatty acid metabolism (15+/-11 mu mol . h(-1). g dry wt(-1), mean+/-SEM), systolic wall thickening (20+/-6%), and myocardial oxygen consumption (3+/-1 mL . min(-1). 100 g(-1)) and an increase in exogenous glucose utilization (75+/-13 mu mol . h(-1). g dry wt(-1)). Systolic wall thickening recovered by only 8+/-3% with reperfusion. Initial distribution of BMS-181321 in the aerobic hearts appeared homogeneous. Washout fromthe ischemic and reperfused LAD bed was slower than the aerobically perfused LAD bed in the control group (t(1/2)=136+/-1 versus 80+/-1 minutes, P<.05), allowing visualization of the LAD region during reperfusion. Tissue activity of BMS-181321 was inversely related to LAD blood flow during ischemia (r=-.68+/-.05), and the ratio of BMS-181321 in the LAD region versus normal myocardium was 1.7+/-0.2. Control swine lacked regional deposition of the tracer in the normally perfused LAD distribution. Conclusions Thus, acute regional ischemia in these studies was visualized as an increase in retention of BMS-181321, suggesting its applicability in the imaging of clinical conditions of myocardial hypoperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:34:34