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Titolo:
THE EFFECT OF NITRIC-OXIDE DONORS ON THE RELEASE OF PLASMINOGEN-ACTIVATOR INHIBITOR (PAI) FROM RABBIT PLATELETS IN-VITRO
Autore:
KORBUT R; MARCINKIEWICZ E; CIESLIK K; GRYGLEWSKI RJ;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL,GRZEGORZECKA 16 PL-31531 KRAKOW POLAND
Titolo Testata:
Journal of Physiology and Pharmacology
fascicolo: 1, volume: 46, anno: 1995,
pagine: 37 - 44
SICI:
0867-5910(1995)46:1<37:TEONDO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROVASODILATORS; NITROPRUSSIDE; PROSTACYCLIN;
Keywords:
NITRIC OXIDE (NO); NITRIC OXIDE DONORS; NITROVASODILATORS; PLASMINOGEN ACTIVATOR INHIBITOR (PAI); PLATELETS FIBRINOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R. Korbut et al., "THE EFFECT OF NITRIC-OXIDE DONORS ON THE RELEASE OF PLASMINOGEN-ACTIVATOR INHIBITOR (PAI) FROM RABBIT PLATELETS IN-VITRO", Journal of Physiology and Pharmacology, 46(1), 1995, pp. 37-44

Abstract

Here we describe effects of four nitric oxide (NO) donors, 4-arylsubstituted oxatriazol derivatives and 3-morpholino-sydnonimine (SIN-1) atconcentrations of 30-1000 mu M on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro. At 37 degrees C, pH of 7.4 and a concentration of 30 mu M, all compounds released NO as measured by the Werringloer's technique. The NO-generating potency of the compounds correlated with their capacity to inhibit the release of PAI from platelets and both phenomena were concentration-dependent. We conclude that various types of NO-donors activate plasma fibrinolytic system through inhibition of the release of PAI from platelets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:44:56