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Titolo:
AUTOMATION OF THE SOCIAL-INTERACTION TEST BY A VIDEO-TRACKING SYSTEM - BEHAVIORAL-EFFECTS OF REPEATED PHENCYCLIDINE TREATMENT
Autore:
SAMSDODD F;
Indirizzi:
H LUNDBECK & CO AS,PHARMACOL RES,OTTILIAVEJ 9 DK-2500 VALBY DENMARK
Titolo Testata:
Journal of neuroscience methods
fascicolo: 2, volume: 59, anno: 1995,
pagine: 157 - 167
SICI:
0165-0270(1995)59:2<157:AOTSTB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOTYPED BEHAVIOR; LOCOMOTOR-ACTIVITY; RATS; ANXIETY; ATAXIA;
Keywords:
ANIMAL MODEL; ETHOVISION; PHENCYCLIDINE; SCHIZOPHRENIA; SOCIAL BEHAVIOR; SOCIAL INTERACTION TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
F. Samsdodd, "AUTOMATION OF THE SOCIAL-INTERACTION TEST BY A VIDEO-TRACKING SYSTEM - BEHAVIORAL-EFFECTS OF REPEATED PHENCYCLIDINE TREATMENT", Journal of neuroscience methods, 59(2), 1995, pp. 157-167

Abstract

The social interaction test is a valuable behavioural model for testing anxiolytic and neuroleptic drugs. The test quantifies the level of social behaviour between pairs of rats and it is usually based on manual analysis of behaviour. Advances in computer technology have made itpossible to track the movements of pairs of rats in an arena, and thepresent paper describes the automation of the social interaction testby the commercial video-tracking programme, the EthoVision(R) system. The ability of the automated system to correctly measure the social behaviour of rats is demonstrated by determining a dose-response relationship in the social interaction test for phencyclidine, a psychotomimetic drug that reduces social behaviour between pairs of rats. These data are subsequently analysed by the manual and automated data-acquisition methods and the results are compared. The study shows that the automated data-acquisition method best describes the behavioural effectsof phencyclidine in the social interaction test by the locomotor activity of the rats, how much time the rats spend in different sections of the testing arena, and the level of social behaviour. Correlation analysis of the results from the manual and automated data-acquisition methods shows that the social behaviour measured by the automated system corresponds correctly to the social behaviour measured by the manualanalysis. The present study has shown that the automated data-acquisition method can quantify locomotor activity, how rats use a testing arena and the level of social behaviour between rats in the social interaction test. The system cannot distinguish between social and aggressive behaviours, and therefore the rats should be tested in an unfamiliar arena to reduce territorial behaviour. Taking this limitation into consideration, the social interaction test can be automated by this computer-based video-tracking system and can be used as a routine test for quantifying the effects of drugs on the social behaviour of rats.

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Documento generato il 10/04/20 alle ore 01:56:32