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Titolo:
SURVIVAL TO LIPOPOLYSACCHARIDE, CYTOKINE RELEASE AND PHAGOCYTE FUNCTIONS IN MICE TREATED WITH DIFFERENT TOTAL PARENTERAL-NUTRITION REGIMENS
Autore:
TUFANO MA; ROSSI F; ROSSANO F; CATALANOTTI P; STELLA L; SERVILLO G; TUFANO R;
Indirizzi:
UNIV NAPLES 2,FAC MED & CHIRURG,IST MICROBIOL NAPLES ITALY UNIV NAPLES 2,FAC MED & CHIRURG,IST FARMACOL & TOSSICOL NAPLES ITALY UNIV MESSINA,FAC MED & CHIRURG,IST MICROBIOL MESSINA ITALY UNIV NAPLES FEDERICO II,FAC MED & CHIRURG,IST ANESTESIA RIANIMAZ & TERAPIA INTENS NAPLES ITALY
Titolo Testata:
Immunopharmacology and immunotoxicology
fascicolo: 3, volume: 17, anno: 1995,
pagine: 493 - 509
SICI:
0892-3973(1995)17:3<493:STLCRA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY-PROTEIN; FAT EMULSIONS; INTERLEUKIN-6; INTERFERON; INFECTION; IL-1; TNF; MACROPHAGES; LEUKOCYTES; MIGRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Tufano et al., "SURVIVAL TO LIPOPOLYSACCHARIDE, CYTOKINE RELEASE AND PHAGOCYTE FUNCTIONS IN MICE TREATED WITH DIFFERENT TOTAL PARENTERAL-NUTRITION REGIMENS", Immunopharmacology and immunotoxicology, 17(3), 1995, pp. 493-509

Abstract

Effects on host defenses of Total Parenteral Nutrition (TPN) with long- (LCT) and medium-chain triglycerides (MCT) were studied. Survival to lipopolysaccharide (LPS) challenge, blood clearance of Escherichia coli, in vivo and in vitro production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were investigated. In BALB/c mice, LCTs produced a 25% reduction in mortality, compared with controls. TPN performed with a LCT plus MCT mixture reduced mortality by 50%. Spasms appeared after 18 h and 12 h respectively in mice treated with LCT-MCT mixture or LCTs alone, respect to controls (8 h). The LCT-MCT mixture produced a 67% blood clearance of E. Coli after 1 h, while the treatment with LCTs alone had no significant effects compared to controls(about 40%). The LC T-MCT mixture induced a 50% increase in chemiluminescence respect to controls. A 33% increase was observed in rats treated with LCTs alone. TNF-alpha serum levels after challenge with LPS were not modified by any of the triglycerides or their combinations. IL-6 increased by 43% with LCT-MCT mixture and by 39% with LCTs alone versus controls. After a 3 h in vitro treatment with LCTs, human monocytes were stimulated to release TNF-alpha at levels higher than those stimulated with the LCT-MCT mixture, and respect to controls. In contrast after 3 h the stimulation with LCT-MCT mixture induced a higher IL-6release than controls and cells stimulated with LCTs alone, or with LPS.

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Documento generato il 25/09/20 alle ore 09:18:19