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Titolo:
COMPARISON OF HUMAN-IMMUNODEFICIENCY-VIRUS BIOLOGICAL PHENOTYPES ISOLATED FROM CEREBROSPINAL-FLUID AND PERIPHERAL BLEED
Autore:
PEETERS MF; COLEBUNDERS RL; VANDENABBEELE K; NYS PC; GOEMAN J; COLANS P; GEERTS Y; VANDERGROEN G;
Indirizzi:
INST TROP MED,DEPT INFECT & IMMUN,NATL STR 155 B-2000 ANTWERP BELGIUM INST TROP MED,DEPT INFECT & IMMUN B-2000 ANTWERP BELGIUM UNIV ANTWERP HOSP,DEPT NEUROL ANTWERP BELGIUM
Titolo Testata:
Journal of medical virology
fascicolo: 1, volume: 47, anno: 1995,
pagine: 92 - 96
SICI:
0146-6615(1995)47:1<92:COHBPI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIROLOGICAL MARKERS; AIDS ENCEPHALOPATHY; TYPE-1 CLONES; III INFECTION; HTLV-III; HIV-1; CAPACITY; FEATURES; BRAIN; IDENTIFICATION;
Keywords:
HIV; VIRAL LOAD; VIRAL PHENOTYPE; CEREBROSPINAL FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Peeters et al., "COMPARISON OF HUMAN-IMMUNODEFICIENCY-VIRUS BIOLOGICAL PHENOTYPES ISOLATED FROM CEREBROSPINAL-FLUID AND PERIPHERAL BLEED", Journal of medical virology, 47(1), 1995, pp. 92-96

Abstract

Quantitative human immunodeficiency virus (HIV) cultures were carriedout on cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMCs), and plasma from patients with HIV in order to compare the infectious HIV load. The HIV strains isolated were studied for syncytium-inducing (SI) capacity, using the MT-2 cell line, in order to compare the HIV strain phenotype of blood and CSF isolates. Forty-two patientswith HIV-1 infection were enrolled in the study, 33 of whom had neurological symptoms and 9 of whom were without neurological symptoms. HIVwas isolated from 16 (38%) of the 42 CSF cultures, with a low mean titer of 6.3 +/- 3.4 tissue-culture-infective doses (TCID) per milliliter. Patients with HIV-positive of CSF culture had a viral load in PBMCsof 40.5 +/- 15.5 TCID per 10(6) PBMC and in plasma of 104.7 +/- 9.3 per milliliter. Two (15%) of the 13 CSF isolates were SI strains, compared to 17 (55.6%) of the 30 PBMC isolates and 13 (54%) of the 24 plasma isolates (P < 0.05). Five of the nine patients from whom CSF and blood strains were obtained had the same viral biological phenotype. Thisstudy suggests that different HIV variants may be found in different body fluids and/or cells. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:38:17