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Titolo:
COMPARISON OF 2 PET RADIOLIGANDS FOR IMAGING EXTRASTRIATAL DOPAMINE TRANSPORTERS IN HUMAN BRAIN
Autore:
WANG GJ; VOLKOW ND; FOWLER JS; DING YS; LOGAN J; GATLEY SJ; MACGREGOR RR; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT RADIOL STONY BROOK NY 11794 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
Life sciences
fascicolo: 14, volume: 57, anno: 1995,
pagine: 187 - 191
SICI:
0024-3205(1995)57:14<187:CO2PRF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE BINDING-SITES; RAT; ACETYLCHOLINE; RECEPTOR; RELEASE;
Keywords:
EXTRASTRIATAL DOPAMINE TRANSPORTER; [C-11] COCAINE; [C-11] D-THREO-METHYLPHENIDATE; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Wang et al., "COMPARISON OF 2 PET RADIOLIGANDS FOR IMAGING EXTRASTRIATAL DOPAMINE TRANSPORTERS IN HUMAN BRAIN", Life sciences, 57(14), 1995, pp. 187-191

Abstract

We compared the sensitivity of two dopamine transporter (DAT) ligands([C-ll]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21-49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum (B-max'/K-d'+ 1). DAT availability measured with [C-11]d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-ll]cocaine. Specific binding (B-max'/K-d') of [C-ll]cocaine in thalamus was 25-33% that of basal ganglia and [C-ll]d-threo-methylphenidate in thalamus was 11-13% that of basal ganglia. The regional measures with [C-ll]cocaine were significantly correlated with those of [C-ll]d-threo-methylphenidate (p less than or equal to 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:56:14