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Titolo:
TISSUE DISTRIBUTION, METABOLISM AND EFFECTS OF BUFOTENINE ADMINISTERED TO RATS
Autore:
FULLER RW; SNODDY HD; PERRY KW;
Indirizzi:
ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Neuropharmacology
fascicolo: 7, volume: 34, anno: 1995,
pagine: 799 - 804
SICI:
0028-3908(1995)34:7<799:TDMAEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM CORTICOSTERONE; SEROTONIN;
Keywords:
BUFOTENINE; SEROTONIN; N-METHYLSEROTONIN; 5-HYDROXYINDOLEACETIC ACID; MONOAMINE OXIDASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Fuller et al., "TISSUE DISTRIBUTION, METABOLISM AND EFFECTS OF BUFOTENINE ADMINISTERED TO RATS", Neuropharmacology, 34(7), 1995, pp. 799-804

Abstract

Bufotenine (N,N-dimethyl-5-hydroxytryptamine) is a serotonin analog reported to be hallucinogenic. Bufotenine concentrations were measured by liquid chromatography with electrochemical detection after the s.c.injection of bufotenine (1,30 or 100 mg/kg) into rats. At 1 hr, bufotenine was high in lung, heart and blood and lower in brain and liver. No N-monomethyl-5-hydroxytryptamine was detected, but 5-hydroxyindoleacetic acid (5HIAA) was increased due to bufotenine metabolism. Bufotenine disappeared nearly completely by 8 hr. Bufotenine concentrations were slightly higher in hypothalamus and brain stem than in striatum orcortex; serotonin was slightly decreased, and 5HIAA was increased in these brain regions. Pargyline reduced concentrations of 5HIAA in blood and tissues after bufotenine injection; LY51641 but not deprenyl mimicked pargyline, suggesting type A not type B monoamine oxidase metabolizes bufotenine. Bufotenine injection increased serum corticosterone concentration, an effect not blocked by metergoline at a dose that blocked a similar increase elicited by quipazine. Although only 2% of theserotonin was found in platelet-poor plasma, more than 99% of the bufotenine was found in platelet-poor plasma, indicating that bufotenine is not stored in platelets. These experiments indicate that bufotenineis rapidly eliminated, in part by type A monoamine oxidase, after itsinjection into rats and that bufotenine penetrates the blood-brain barrier poorly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:42:31