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Titolo:
RADIAL AND HORIZONTAL DEPLOYMENT OF CLONALLY RELATED CELLS IN THE PRIMATE NEOCORTEX - RELATIONSHIP TO DISTINCT MITOTIC LINEAGES
Autore:
KORNACK DR; RAKIC P;
Indirizzi:
YALE UNIV,SCH MED,NEUROBIOL SECT NEW HAVEN CT 06510
Titolo Testata:
Neuron
fascicolo: 2, volume: 15, anno: 1995,
pagine: 311 - 321
SICI:
0896-6273(1995)15:2<311:RAHDOC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CEREBRAL-CORTEX; CHICKEN OPTIC TECTUM; RECOMBINANT RETROVIRUS; MIGRATION PATTERNS; COMMON PROGENITOR; VISUAL-CORTEX; MONKEY BRAIN; MOUSE; NEURONS; DISPERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Kornack e P. Rakic, "RADIAL AND HORIZONTAL DEPLOYMENT OF CLONALLY RELATED CELLS IN THE PRIMATE NEOCORTEX - RELATIONSHIP TO DISTINCT MITOTIC LINEAGES", Neuron, 15(2), 1995, pp. 311-321

Abstract

To analyze cell lineage in the rhesus monkey neocortex, we used recombinant retroviruses to label individual progenitor cells in the ventricular zone (VZ), then determined histochemically the distribution of their progeny during and after the period of cortical neurogenesis. Distribution patterns of labeled cells in the VZ suggested the coexistence of asymmetrically and symmetrically dividing progenitor cells, indicating that both postmitotic and mitotic progeny are produced during cortical neurogenesis. In the cortex, several distinct patterns of clonal distribution were observed and interpreted as follows: clones aligned radially suggested that asymmetrically dividing progenitors generatesequential ''siblings'' that migrate, in tandem, along a common radial path to the cortex. In contrast, clones oriented horizontally withina single lamina suggested that symmetric divisions produce multiple, laterally displaced progenitors which, in turn, simultaneously generate ''cousin'' cells that migrate, in concert, to the same cortical layer. Thus, we propose that different mitotic lineages, which coexist in the monkey VZ, produce distinct radial or laminar patterns of clone deployment that foreshadow the cytological organization of the adult neocortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:03:38