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Titolo:
EFFECT OF AGING ON ATENOLOL PHARMACOKINETICS AND PHARMACODYNAMICS
Autore:
SOWINSKI KM; FORREST A; WILTON JH; TAYLOR AM; WILSON MF; KAZIERAD DJ;
Indirizzi:
MILLARD FILLMORE HOSP,CLIN PHARMACOKINET LAB,3 GATES CIRCLE BUFFALO NY 14209 MILLARD FILLMORE HOSP,CLIN PHARMACOKINET LAB BUFFALO NY 14209 SUNY COLL BUFFALO,SCH PHARM,CTR CLIN PHARM RES BUFFALO NY 14222 MILLARD FILLMORE HOSP,DEPT MED BUFFALO NY 14209
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 8, volume: 35, anno: 1995,
pagine: 807 - 814
SICI:
0091-2700(1995)35:8<807:EOAOAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC SENSITIVITY; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Sowinski et al., "EFFECT OF AGING ON ATENOLOL PHARMACOKINETICS AND PHARMACODYNAMICS", Journal of clinical pharmacology, 35(8), 1995, pp. 807-814

Abstract

A study was conducted to characterize and compare the pharmacodynamics and pharmacokinetics of atenolol in young and elderly men. Six young(mean +/- SD, 25.0 +/- 3.0 years) and six elderly (63.0 +/- 3.2 years) healthy men took atenolol 100 mg orally once daily for 6 days. Heartrate response to submaximal exercise was measured at selected times for 48 hours, and plasma and urine samples were collected over the sametime interval. The Sigmoid E(max) model was fit to percent reductionsin exercise heart rate and atenolol plasma concentrations. The younger men had significantly lower values for area under the steady-state plasma concentration-time curve and higher values for systemic clearance/F and renal clearance. EC(50) values showed a trend reward greater sensitivity to the negative chronotropic effects of atenolol among the elderly men. Model-derived percent reductions in heart rate were greater at all concentrations among the elderly men. These data suggest that group differences in atenolol pharmacokinetics were likely a result of age-related decline in renal function, and that the elderly subjects were at least as sensitive as, and maybe even more sensitive than, the younger subjects to the negative chronotropic effects of atenolol.

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Documento generato il 23/10/20 alle ore 11:13:42