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Titolo:
RESTENOSIS AFTER CORONARY ANGIOPLASTY
Autore:
HAMON M; BAUTERS C; MCFADDEN EP; WERNERT N; LABLANCHE JM; DUPUIS B; BERTRAND ME;
Indirizzi:
HOP CARDIOL,SERV CARDIOL B & HEMODYNAM,BLVD PROF J LECLERCQ F-59037 LILLE FRANCE UNIV LILLE,DEPT CARDIOL LILLE FRANCE UNIV LILLE,DEPT PATHOL LILLE FRANCE UNIV LILLE,DEPT PHARMACOL LILLE FRANCE
Titolo Testata:
European heart journal
, volume: 16, anno: 1995, supplemento:, I
pagine: 33 - 48
SICI:
0195-668X(1995)16:<33:RACA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; RAT CAROTID-ARTERY; GROWTH-FACTOR-BETA; ANGIOTENSIN-CONVERTING ENZYME; MYC MESSENGER-RNA; BALLOON ANGIOPLASTY; C-MYC; RABBIT AORTA; EXTRACELLULAR-MATRIX; VASCULAR INJURY;
Keywords:
CORONARY ANGIOPLASTY; RESTENOSIS; SMOOTH MUSCLE CELL; BALLOON DENUDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
163
Recensione:
Indirizzi per estratti:
Citazione:
M. Hamon et al., "RESTENOSIS AFTER CORONARY ANGIOPLASTY", European heart journal, 16, 1995, pp. 33-48

Abstract

The major disadvantage of using percutaneous transluminal coronary angioplasty to treat patients with atherosclerotic coronary disease is the frequent occurrence of restenosis after an initially successful procedure. Studies in animals and histological observations in man have demonstrated that restenosis is characterized by neointimal hyperplasiadue to smooth muscle cell proliferation and to the synthesis of extracellular matrix. Improvements in technology or pharmacological interventions have had no significant impact on the rate of restenosis. In spite of our increased understanding of the molecular mechanisms of restenosis, no effective treatment is available at the present time. Gene therapy which has produced encouraging initial results in experimentalmodels, may provide a solution in the medium term.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:31:32