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Titolo:
DORSAL PERIAQUEDUCTAL GRAY-INDUCED AVERSION AS A SIMULATION OF PANIC ANXIETY - ELEMENTS OF FACE AND PREDICTIVE-VALIDITY
Autore:
JENCK F; MOREAU JL; MARTIN JR;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,PRECLIN CNS RES,DIV PHARMA,B72-R1478 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Psychiatry research
fascicolo: 2, volume: 57, anno: 1995,
pagine: 181 - 191
SICI:
0165-1781(1995)57:2<181:DPGAAA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRICAL-STIMULATION; MINOR TRANQUILIZERS; KINDLING MODEL; ANIMAL-MODELS; DISORDER; ATTACKS; AGORAPHOBIA; MECHANISMS; CLONAZEPAM; CAFFEINE;
Keywords:
ANIMAL MODEL; ANXIETY DISORDER; INTRACEREBRAL STIMULATION; ALPRAZOLAM; CLONAZEPAM; YOHIMBINE; CAFFEINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
F. Jenck et al., "DORSAL PERIAQUEDUCTAL GRAY-INDUCED AVERSION AS A SIMULATION OF PANIC ANXIETY - ELEMENTS OF FACE AND PREDICTIVE-VALIDITY", Psychiatry research, 57(2), 1995, pp. 181-191

Abstract

Neurosurgical stimulation of the dorsal periaqueductal gray (dPAG) matter in man induces acute signs of autonomic arousal and feelings of subjective anxiety; those signs have phenomenological similarity with the symptom profile characterizing a panic attack. Animals undergoing dPAG stimulation show comparable physical signs of autonomic activationand sudden fear-suggestive behavioral reactions that can be shaped into operant self-interruption behavior. Drugs known to acutely reduce (alprazolam, clonazepam) or precipitate (yohimbine, caffeine) panic attacks in patients were found to acutely and dose-dependently reduce or enhance, respectively, aversion induced by dPAG stimulation in rats. When considered as an animal model of panic anxiety, the dPAG model simultaneously meets criteria of face validity (symptomatic homology) andpredictive validity (pharmacological homology under short-term treatment); aspects of its construct validity (theoretical rationale supporting the model) are discussed. It is suggested that dPAG stimulation-induced aversion may represent a model of some aspects of panic disorders.

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Documento generato il 26/01/20 alle ore 22:18:40