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Titolo:
NF-KAPPA-B AND TRANSCRIPTIONAL CONTROL OF RENAL EPITHELIAL-INDUCIBLE NITRIC-OXIDE SYNTHASE
Autore:
AMOAHAPRAKU B; CHANDLER LJ; HARRISON JK; TANG SS; INGELFINGER JR; GUZMAN NJ;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT PHARMACOL,HSC,POB 100267 GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT PHARMACOL GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DIV NEPHROL HYPERTENS & TRANSPLANTAT GAINESVILLE FL 32610 MASSACHUSETTS GEN HOSP,DIV PEDIAT NEPHROL BOSTON MA 00000 HARVARD UNIV,SCH MED BOSTON MA 00000
Titolo Testata:
Kidney international
fascicolo: 3, volume: 48, anno: 1995,
pagine: 674 - 682
SICI:
0085-2538(1995)48:3<674:NATCOR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL LIPOPOLYSACCHARIDE; MOUSE MACROPHAGES; PERITONEAL-MACROPHAGES; IFN-GAMMA; GENE; INDUCTION; EXPRESSION; PROMOTER; TUBULE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
B. Amoahapraku et al., "NF-KAPPA-B AND TRANSCRIPTIONAL CONTROL OF RENAL EPITHELIAL-INDUCIBLE NITRIC-OXIDE SYNTHASE", Kidney international, 48(3), 1995, pp. 674-682

Abstract

Expression of the inducible isoform of nitric oxide synthase (iNOS) is subject to strict tissue specific transcriptional control. Recently,the NF-kappa B/Rel family of transcription factors, and particularly c-rel, was shown to mediate bacterial lipopolysaccharide (LPS) induction of iNOS in macrophages. Since LPS is only a weak inducer of iNOS inmost nonimmune cells, we investigated the role of NF-kappa B in the regulation of iNOS expression in mouse renal epithelial cells. We report that LPS activates NF-kappa B in renal epithelium, but that this is not sufficient for induction of iNOS activity. The NF-kappa B complexes activated by LPS in renal epithelium differ from those in macrophages in that they lack c-rel, which may explain the absence of iNOS induction in renal epithelium. Conversely, LPS and interferon-gamma (IFN) synergize to induce renal epithelial iNOS. Functional iNOS promoter analysis indicate that this synergistic induction requires NF-kappa B. Weconclude that NF-kappa B is necessary but not sufficient for the induction of renal epithelial iNOS expression, and that in contrast to macrophages, c-rel does not appear to play a major role in the regulationof renal epithelial iNOS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:08:50