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Titolo:
POLY(ADP-RIBOSE) SYNTHETASE ACTIVATION - AN EARLY INDICATOR OF NEUROTOXIC DNA-DAMAGE
Autore:
ZHANG J; PIEPER A; SNYDER SH;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,725 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT BALTIMORE MD 21205 GUILFORD PHARMACEUT INC BALTIMORE MD 00000
Titolo Testata:
Journal of neurochemistry
fascicolo: 3, volume: 65, anno: 1995,
pagine: 1411 - 1414
SICI:
0022-3042(1995)65:3<1411:PSA-AE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADP-RIBOSYLATION; NEURONS; PROTECTION; METABOLITE; APOPTOSIS; DISEASE; PROTEIN;
Keywords:
ALZHEIMERS DISEASE; AMYLOID BETA-PROTEIN; MPTP NEUROTOXICITY; PARKINSONS DISEASE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J. Zhang et al., "POLY(ADP-RIBOSE) SYNTHETASE ACTIVATION - AN EARLY INDICATOR OF NEUROTOXIC DNA-DAMAGE", Journal of neurochemistry, 65(3), 1995, pp. 1411-1414

Abstract

DNA damage activates a nuclear enzyme poly(ADP-ribose) synthetase (PARS) that facilitates DNA repair by adding multiple ADP-ribose groups to nuclear proteins such as histones and PARS itself. N-Methyl-D-aspartate neurotoxicity may involve DNA damage excessively activating PARS to deplete its substrate NAD, as PARS inhibitors prevent this toxicity. We now show that PARS is rapidly and markedly activated in PC12 cellsfollowing treatment with neurotoxic agents, including the amyloid beta-protein, hydrogen peroxide, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and its active metabolite N-methyl-4-phenylpyridine (MPP()). With MPP(+), PARS activity is increased fivefold in 1 h and 20-fold by 3 h. By contrast, direct measurement of DNA damage by the terminal-deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labelingassay shows no significant increase by 3 h and less than fourfold by 24 h. These findings indicate that PARS activity can provide a simple,sensitive, and early index of DNA damage following neurotoxic insults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:57:25