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Titolo:
ROLE OF MUCOSAL MICROCIRCULATION IN GASTRIC-LESIONS INDUCED BY LATERAL HYPOTHALAMIC-LESIONS IN RATS
Autore:
SAITA H; MURAKAMI M; KITA T;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT GERIATR MED,SAKYO KU,54 KAWAHARA CHO KYOTO 606 JAPAN KYOTO UNIV,FAC MED,DEPT GERIATR MED,SAKYO KU KYOTO 606 JAPAN
Titolo Testata:
Journal of gastroenterology and hepatology
fascicolo: 4, volume: 10, anno: 1995,
pagine: 371 - 378
SICI:
0815-9319(1995)10:4<371:ROMMIG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID SECRETION; BLOOD-FLOW; DAMAGE;
Keywords:
GASTRIC MUCOSAL LESIONS; GASTRIC MUCOSAL MICROCIRCULATION; GASTRIC MUCUS; LATERAL HYPOTHALAMIC LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H. Saita et al., "ROLE OF MUCOSAL MICROCIRCULATION IN GASTRIC-LESIONS INDUCED BY LATERAL HYPOTHALAMIC-LESIONS IN RATS", Journal of gastroenterology and hepatology, 10(4), 1995, pp. 371-378

Abstract

To evaluate the pathophysiology underlying gastric mucosal lesions induced by lateral hypothalamic (LH) lesions, we investigated the changes in acid secretion, gastric mucosal blood flow, gastric mucus and mucosal integrity in the corpus during the 4 h period and 48 h after the production of bilateral electrolytic LH lesions in male Sprague-Dawleyrats. Gastric mucosal lesions were macroscopically produced 24 h (63%) and 48 h (83%) after LH lesions, although there were no visible lesions at 7 h. Gastric acid secretion was significantly increased 48 h after LH lesions, compared with that in the control group. Gastric mucosal blood flow and transmucosal potential difference (PD) in the LH lesion group immediately decreased after LH lesions and did not recover during 4 h and at 48 h. On the contrary, in the control group, gastric mucosal blood flow decreased after the brain surgery but soon recovered, and there was no significant change in PD. LH lesions resulted in the reduction of intramucosal mucus to 50% 3 h after LH lesions. Moreover, we exposed the stomach to 10 mmol/L taurocholic acid (TCA) 3 h after LH lesions to examine the disruption in gastric mucosal defensive function in rats with LH lesions. The recovery of the reduced PD by TCAwas slow and gastric mucosal lesions were easily formed in the LH lesion group. These results suggest that gastric mucosal ischaemia after lesioning of LH immediately results in the disruption of mucosal defensive function before the formation of visible gastric lesions, and predisposes to the formation of gastric mucosal lesions by a delayed increase in acid secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:54:24