Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VOLUNTEER BLOOD-DONORS WITH ANTIBODY TO HEPATITIS-C VIRUS - CLINICAL,BIOCHEMICAL, VIROLOGICAL, AND HISTOLOGIC FEATURES
Autore:
SHAKIL AO; CONRYCANTILENA C; ALTER HJ; HAYASHI P; KLEINER DE; TEDESCHI V; KRAWCZYNSKI K; CONJEEVARAM HS; SALLIE R; DIBISCEGLIE AM; MELPOLDER JC; HOOFNAGLE JH;
Indirizzi:
NIH,LIVER DIS SECT,BLDG 10,ROOM 4D52 BETHESDA MD 20892 NIH,LIVER DIS SECT BETHESDA MD 20892 CTR DIS CONTROL & PREVENT ATLANTA GA 00000
Titolo Testata:
Annals of internal medicine
fascicolo: 5, volume: 123, anno: 1995,
pagine: 330 - 337
SICI:
0003-4819(1995)123:5<330:VBWATH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-B-HEPATITIS; NON-A-HEPATITIS; LIVER-DISEASE; POSTTRANSFUSION HEPATITIS; UNITED-STATES; INFECTION; SERUM; HCV; RNA; HISTORY;
Keywords:
HEPATITIS C; HEPATITIS C VIRUSES; HEPATITIS ANTIBODIES; BLOOD DONORS; ALANINE AMINOTRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A.O. Shakil et al., "VOLUNTEER BLOOD-DONORS WITH ANTIBODY TO HEPATITIS-C VIRUS - CLINICAL,BIOCHEMICAL, VIROLOGICAL, AND HISTOLOGIC FEATURES", Annals of internal medicine, 123(5), 1995, pp. 330-337

Abstract

Objective: To assess the clinical significance of antibody to hepatitis C virus (anti-HCV) in volunteer blood donors. Design: Prospective cohort study. Setting: National Institutes of Health Clinical Center, atertiary referral research hospital. Patients: 60 anti-HCV-positive blood donors, divided into three groups of 20 persons each: Group I hadnormal alanine aminotransferase levels, group II had levels elevated to values less than twice the normal range, and group HI had levels elevated to values greater than twice the normal range. Measurements: Medical history, results of laboratory and virologic testing, and percutaneous liver biopsy findings. Results: Participants with normal alanine aminotransferase levels were older and more often female than those with abnormal levels. The source of infection, duration of disease, symptom score, and amount of alcohol consumed were similar in the three groups. Hepatitis C virus RNA was detectable in 85% of participants, more commonly in the groups with elevated alanine aminotransferase levels (95%) than in the group with normal levels (65%); however, titers were similar in all groups. Examination of liver biopsy specimens showed chronic hepatitis in 54 participants (90%) and cirrhosis in 1 participant. The only normal liver biopsy specimens (n = 3) were those from participants who were HCV RNA negative and had normal alanine aminotransferase levels. Conclusions: Most blood donors with anti-HCV have chronic hepatitis C regardless of their serum alanine aminotransferase levels. Donors with normal alanine aminotransferase levels and no HCV RNA in their serum generally have normal liver histologic findings or minimal changes and have probably recovered from HCV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/06/20 alle ore 06:16:46