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Titolo:
HIGH-RESOLUTION MACROMOLECULAR STRUCTURE DETERMINATION USING CCD DETECTORS AND SYNCHROTRON-RADIATION
Autore:
WALTER RL; THIEL DJ; BARNA SL; TATE MW; WALL ME; EIKENBERRY EF; GRUNER SM; EALICK SE;
Indirizzi:
CORNELL UNIV,BIOCHEM SECT ITHACA NY 14853 CORNELL UNIV,BIOCHEM SECT ITHACA NY 14853 PRINCETON UNIV,DEPT PHYS PRINCETON NJ 08544 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT PATHOL PISCATAWAY NJ 08854
Titolo Testata:
Structure
fascicolo: 8, volume: 3, anno: 1995,
pagine: 835 - 844
SICI:
0969-2126(1995)3:8<835:HMSDUC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURINE NUCLEOSIDE PHOSPHORYLASE; X-RAY-DIFFRACTION; PROTEIN CRYSTALLOGRAPHY; 3-DIMENSIONAL STRUCTURE; CONCANAVALIN-A; IMAGING PLATE; CRYSTALLIZATION; CRYSTALS; SYSTEM; DOMAIN;
Keywords:
CHARGE-COUPLED DEVICE (CCD); MACROMOLECULAR STRUCTURE; SYNCHROTRON RADIATION; X-RAY DETECTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Walter et al., "HIGH-RESOLUTION MACROMOLECULAR STRUCTURE DETERMINATION USING CCD DETECTORS AND SYNCHROTRON-RADIATION", Structure, 3(8), 1995, pp. 835-844

Abstract

Background: Synchrotron. radiation sources have made impressive contributions to macromolecular crystallography. The delay in development of appropriate X-ray detectors has, however, been a significant limitation to their efficient use. New technologies, based on charge-coupled devices (CCDs), provide capabilities for faster, more accurate, automated data collection. Results: A CCD-based X-ray detector has been developed for use in macromolecular crystallography and has been in operation for about one and a half years at the Cornell High Energy Synchrotron Source. It has been used for a variety of crystallographic projects, including a number of high-resolution structural studies. The statistical quality of the data, the detector's ease and efficiency of use,and the growing number of structural results illustrate the practicalutility of this new detector system. Conclusions: The new detector has enhanced capabilities for measuring diffraction patterns from crystals of macromolecules, especially at high resolution, when the X-ray intensities are weak. The survey of results described here ranges from virus crystallography to weakly diffracting small-molecule structure determination and demonstrates the potential of CCD detectors when combined with synchrotron radiation sources.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:35:05