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Titolo:
ASSESSMENT OF EFFECTS OF INTRAVENOUS DIPYRIDAMOLE ON REGIONAL MYOCARDIAL PERFUSION IN CHILDREN WITH KAWASAKI-DISEASE WITHOUT ANGIOGRAPHIC EVIDENCE OF CORONARY STENOSIS USING POSITRON EMISSION TOMOGRAPHY AND (H2O)-O-15
Autore:
OHMOCHI Y; ONOUCHI Z; ODA Y; HAMAOKA K;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,CHILDRENS RES HOSP,DIV PEDIAT,KAMIGYOU KU,465 KAJIICHO KYOTO 602 JAPAN
Titolo Testata:
Coronary artery disease
fascicolo: 7, volume: 6, anno: 1995,
pagine: 555 - 559
SICI:
0954-6928(1995)6:7<555:AOEOID>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; QUANTIFICATION; VELOCITY; RESERVE;
Keywords:
CORONARY ARTERY DISEASE; POSITRON EMISSION TOMOGRAPHY; O-15 LABELED WATER ((H2O)-O-15); MYOCARDIAL BLOOD FLOW; MYOCARDIAL PERFUSION RESERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ohmochi et al., "ASSESSMENT OF EFFECTS OF INTRAVENOUS DIPYRIDAMOLE ON REGIONAL MYOCARDIAL PERFUSION IN CHILDREN WITH KAWASAKI-DISEASE WITHOUT ANGIOGRAPHIC EVIDENCE OF CORONARY STENOSIS USING POSITRON EMISSION TOMOGRAPHY AND (H2O)-O-15", Coronary artery disease, 6(7), 1995, pp. 555-559

Abstract

Background: Positron emission tomography and (H2O)-O-15 were used to characterize regional myocardial blood flow and distribution at rest and in response to dipyridamole in children with Kawasaki disease but without angiographic evidence of coronary stenosis. Method: Patients were classified into two groups on the basis of the results of selectivecoronary angiography: subjects in group I had normal coronary angiograms (n = 4): subjects in group II had aneurysms (n = 5). Results: Myocardial perfusion, assessed with (H2O)-O-15, was homogeneous over all regions at rest and at peak flow in groups I and II. Dipyridamole infusion significantly reduced myocardial perfusion reserve in group II (average 3.56+/-1.03 fold versus 5.06+/-1.37 fold in group I, P < 0.001). Conclusion: Our results suggest that aneurysms associated with Kawasaki disease may reduce myocardial reserve. Non-invasive quantitative assessment of myocardial blood flow with positron emission tomography and (H2O)-O-15 was useful in assessing the functional capacity of coronary artery lesions and the extent of myocardial damage in children withKawasaki disease.

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Documento generato il 03/12/20 alle ore 16:04:02