Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEVELOPMENT OF ELECTRICAL MEMBRANE-PROPERTIES AND DISCHARGE CHARACTERISTICS OF SUPERIOR OLIVARY COMPLEX NEURONS IN FETAL AND POSTNATAL RATS
Autore:
KANDLER K; FRIAUF E;
Indirizzi:
UNIV FRANKFURT,ZENTRUM PHYSIOL,THEODOR STERN KAI 7 D-60590 FRANKFURT GERMANY UNIV TUBINGEN,DEPT ANIM PHYSIOL D-72076 TUBINGEN GERMANY
Titolo Testata:
European journal of neuroscience
fascicolo: 8, volume: 7, anno: 1995,
pagine: 1773 - 1790
SICI:
0953-816X(1995)7:8<1773:DOEMAD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; ANTEROVENTRAL COCHLEAR NUCLEUS; ACTIVATED CATION CURRENT; VOLTAGE-CLAMP ANALYSIS; MEDIAL NUCLEUS; TRAPEZOID BODY; NEUROPHYSIOLOGICAL MATURATION; PHYSIOLOGICAL-PROPERTIES; ANOMALOUS RECTIFICATION; DENDRITIC MORPHOLOGY;
Keywords:
ACTION POTENTIAL; DISCHARGE PATTERN; INTRACELLULAR LABELING; LATERAL SUPERIOR OLIVE; ONTOGENY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
K. Kandler e E. Friauf, "DEVELOPMENT OF ELECTRICAL MEMBRANE-PROPERTIES AND DISCHARGE CHARACTERISTICS OF SUPERIOR OLIVARY COMPLEX NEURONS IN FETAL AND POSTNATAL RATS", European journal of neuroscience, 7(8), 1995, pp. 1773-1790

Abstract

Although hearing onset occurs relatively late during ontogeny of rats[around postnatal day (P) 12], anatomical brainstem connections are formed much earlier and are present before birth, indicating that a substantial amount of maturation occurs without acoustic input. Electrical activity is thought to influence neuronal development, but the physiological properties of auditory brainstem neurons during perinatal maturation are barely known. The present study focuses on the developmentof electrophysiological membrane properties of neurons in the rat's superior olivary complex (SOC), the first binaural station in the mammalian auditory brainstem. In in vitro slice preparations, intracellularrecordings were obtained from 115 SOC cells from embryonic day (E) 18to P17, and cells were morphologically identified by intracellular injection of biocytin or neurobiotin. By E18, i.e. 4 days before birth, SOC neurons were capable of generating Na+-dependent action potentials. Several passive and active membrane properties, including the resting potential, spike threshold and spike amplitude, did not change with development. in contrast, input resistance, time constant and spike duration decreased significantly, and maximal spike frequency increased significantly during the age period sampled. Our results show that ratSOC neurons display mature as well as immature electrical membrane properties during the same developmental period when anatomical connections are refined and when the soma-dendritic morphology develops. We conclude, therefore, that their membrane properties represent adequate physiological adaptations to the immature auditory brainstem microcircuits and that they form a basis upon which the development of these microcircuits is shaped.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:46:39