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Titolo:
THE HCR (HEPATOCARCINOGEN RESISTANCE) LOCI OF DBA 2J MICE PARTIALLY SUPPRESS PHENOTYPIC-EXPRESSION OF THE HCS (HEPATOCARCINOGEN SENSITIVITY) LOCI OF C3H/HEJ MICE/
Autore:
LEE GH; DRINKWATER NR;
Indirizzi:
ASAHIKAWA MED COLL,DEPT PATHOL,4-5-3-11 NISHIKAGURA ASAHIKAWA 078 HOKKAIDO JAPAN UNIV WISCONSIN,SCH MED,MCARDLE LAB CANC RES MADISON WI 53706
Titolo Testata:
Carcinogenesis
fascicolo: 8, volume: 16, anno: 1995,
pagine: 1993 - 1996
SICI:
0143-3334(1995)16:8<1993:TH(RLO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-ALTERED FOCI; QUANTITATIVE STEREOLOGY; LIVER CARCINOGENESIS; INBRED MICE; RAT-LIVER; DIETHYLNITROSAMINE; GROWTH; SUSCEPTIBILITY; HEPATOCYTES; PROMOTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.H. Lee e N.R. Drinkwater, "THE HCR (HEPATOCARCINOGEN RESISTANCE) LOCI OF DBA 2J MICE PARTIALLY SUPPRESS PHENOTYPIC-EXPRESSION OF THE HCS (HEPATOCARCINOGEN SENSITIVITY) LOCI OF C3H/HEJ MICE/", Carcinogenesis, 16(8), 1995, pp. 1993-1996

Abstract

Both male DBA/2J and C3H/HeJ mice are highly susceptible to hepatocarcinogenesis induced by experimental treatment with N,N-diethylnitrosamine (DEN) relative to male C57BL/6J mice, While C3H/HeJ mice carry multiple sensitivity loci, designated Hcs (hepatocarcinogen sensitivity),our previous study indicated that the susceptibility of DBA/2J mice results from the combined effects of multiple sensitivity loci and two major resistance loci, Hcr-1 and -2 (hepatocarcinogen resistance), We proposed that BXD-15 recombinant inbred mice, which are extremely resistant to DEN-induced hepatocarcinogenesis, may carry the Hcr loci fromthe parental DBA/2J mice, but few if any, of the multiple sensitivityloci, Conversely, the extremely sensitive BXD-11 recombinant inbred mice may carry most of the multiple sensitivity loci of the DBA/2J parents, but neither of the major resistance loci, In order to confirm ourgenetic model for hepatocarcinogenesis in DBA/2J mice and to evaluatethe phenotypic effects of the Hcr loci on the Hcs loci of C3H/HeJ mice, we characterized hepatocarcinogen sensitivities of F-1 mice generated from the crosses involving BXD-11, BXD-15, C3H/HeJ and C57BL/6J strains, When male mice were initiated with DEN at 12 days of age and liver tumors were enumerated at 32 weeks of age, (BXD-15 X BXD-11)F-1 mice had one sixth the number of liver tumors observed in (C57BL/6JXBXD-11)F-1 mice, consistent with our previous conclusion that DBA/2J mice possess hepatocarcinogen resistance genes in spite of their high susceptibility to DEN, Significantly, (C57BL/6JXC3H/HeJ)F-1 mice also had a 2.3-fold greater number of liver tumors and 5.5-fold higher total volume of initiated lesions per liver as compared with (BXD-15XC3H/HeJ)F-1mice, indicating that the hepatocarcinogen resistance genes inheritedby BXD-15 mice are capable of suppressing the Hcs phenotype, Thus theHcr loci may influence a wide variety of hepatocarcinogen sensitivityloci and be able to act as general resistance loci for chemical hepatocarcinogenesis, Stereological analysis of initiated hepatocellular lesions with glucose 6-phosphatase deficiency revealed that the resistance genes largely influence the promotion stage of hepatocarcinogenesis.

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Documento generato il 03/12/20 alle ore 16:09:41