Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACTIVATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS LONG TERMINAL REPEAT BY ABRASION OF THE SKIN IN TRANSGENIC MICE
Autore:
MORREY JD; BOURN SM; MORRIS JLB; BUNCH TD; SIDWELL RW;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES,DEPT ANIM DAIRY & VET SCI,BIOTECHNOL BLDG,ROOM 305 LOGAN UT 84322
Titolo Testata:
Intervirology
fascicolo: 6, volume: 37, anno: 1994,
pagine: 315 - 320
SICI:
0300-5526(1994)37:6<315:AOTHLT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LANGERHANS CELLS; HIV INFECTION; EXPRESSION; TYPE-1; LINES; LTR;
Keywords:
HUMAN IMMUNODEFICIENCY VIRUS; LONG TERMINAL REPEAT; TRANSGENIC MICE; WOUNDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Morrey et al., "ACTIVATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS LONG TERMINAL REPEAT BY ABRASION OF THE SKIN IN TRANSGENIC MICE", Intervirology, 37(6), 1994, pp. 315-320

Abstract

Mechanical wounding was shown to activate the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in the skin of transgenic mice. Both noninvasive rubbing and scratching of the skin resultedin a range of 4- to 44-fold increased levels of luciferase reporter gene activities when assayed 24-48 h after wounding. Moreover, long-term noninvasive rubbing each day for 17 days resulted in similar increased levels of luciferase activity. Experiments were done to determine whether the HIV-1 LTR-luciferase transgene might be activated when pupswere nursed on the mammary tissues of transgenic mice. Luciferase reporter gene activity in mammary glands skin following nursing was significantly higher than in skin from non-pregnant transgenic mice or transgenic mice 20 days post-conception, which suggests that the natural abrasive action of nursing resulted in activation of the LTR. These results may have implications for sexual transmission and maternal-to-infant transmission of HIV-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:35:11