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Titolo:
INCREASED SERUM IGE IN ALCOHOL ABUSERS
Autore:
GONZALEZQUINTELA A; VIDAL C; GUDE F; TOME S; LOJO S; LORENZO MJ; BECERRA EP; MARTINEZVAZQUEZ JM; BARRIO E;
Indirizzi:
PLAZA XUNCAL 1,2A,PERILLO OLEIROS E-15172 LA CORUNA SPAIN COMPLEJO HOSP UNIV SANTIAGO,DIV INTERNAL MED SANTIAGO SPAIN COMPLEJO HOSP UNIV SANTIAGO,DIV ALLERGY SANTIAGO SPAIN COMPLEJO HOSP UNIV SANTIAGO,DIV CLIN EPIDEMIOL SANTIAGO SPAIN COMPLEJO HOSP UNIV SANTIAGO,DIV BIOCHEM SANTIAGO SPAIN COMPLEJO HOSP UNIV SANTIAGO,DIV PATHOL SANTIAGO SPAIN
Titolo Testata:
Clinical and experimental allergy
fascicolo: 8, volume: 25, anno: 1995,
pagine: 756 - 764
SICI:
0954-7894(1995)25:8<756:ISIIAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; LIVER-DISEASE; HEPATITIS; ETHANOL; INTERLEUKIN-8; DIAGNOSIS; CYTOKINES; IMMUNITY; CELLS;
Keywords:
SERUM IGE; ALCOHOL ABUSERS; ALCOHOLIC LIVER DAMAGE; INCREASED IGE LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A. Gonzalezquintela et al., "INCREASED SERUM IGE IN ALCOHOL ABUSERS", Clinical and experimental allergy, 25(8), 1995, pp. 756-764

Abstract

Background It has been reported that total serum IgE is increased in patients with alcoholic cirrhosis, but it is not clear if this fact isrelated to alcoholic liver disease or to alcohol intake. Objective Tomeasure serum IgE in a group of chronic alcoholics with different stages of liver injury in order to elucidate if IgE increase is related to alcoholic liver damage. Patients and methods Total serum IgE was determined by enzyme immunoassay in 186 chronic alcoholic patients (137 male/49 female) and 101 healthy controls. Patients and controls with known reasons for IgE elevation were excluded. Among alcoholic patients,24 had fatty liver, 28 hepatic fibrosis, 29 alcoholic hepatitis, and 67 liver cirrhosis (38 patients were not evaluable concerning liver injury). Results Total serum IgE was found to be increased in alcoholics(median 154.5 IU/mL, range 1-7329 IU/mL) with respect to healthy controls (median 20 IU/mL, range <1-1417 IU/mL) (P < 0.001). IgE increase was moderate (180-1000 IU/mL) in 60 alcoholics (32.3%) and marked (> 1000 IU/mL) in 27 (14.5%). Male alcoholics had higher IgE levels than females (median 191 IU/mL and range 1-7329 IU/mL vs 105 IU/mL and range2-2189 IU/mL) (P = 0.009). On logistic regression analysis, alcoholism, male sex and younger age (but not smoking) were independently associated with higher IgE levels. No clear relationship was noted between serum IgE and severity of alcoholic liver disease. Thus, no correlation was observed between IgE and parameters of liver function (serum bilirubin, albumin or prothrombin index). Likewise, IgE concentrations were not significantly different in patients with liver cirrhosis with respect to patients with less severe liver disease. Serum IgE was increased (> 180 IU/mL) in 47.8% of cirrhotics and in 44% of patients without liver cirrhosis. In contrast, other immunoglobulins (IgG, IgA and IgM) were significantly correlated with liver dysfunction.Conclusion Chronic alcoholism should be considered as a cause of increased total serum IgE, regardless of the severity of the underlying liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:23:04