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Titolo:
INTRACELLULAR LEVELS AND SECRETION OF INSULIN-LIKE-GROWTH-FACTOR-BINDING PROTEINS IN MCF-7 6, MCF-7/AZ AND MDA-MB-231 BREAST-CANCER CELLS -DIFFERENTIAL MODULATION BY ESTROGENS IN SERUM-FREE MEDIUM/
Autore:
DUBOIS V; COUISSI D; SCHONNE E; REMACLE C; TROUET A;
Indirizzi:
UNIV CATHOLIQUE LOUVAIN,CELL BIOL LAB,PL CROIX SUD 5 B-1348 LOUVAIN BELGIUM UNIV CATHOLIQUE LOUVAIN,DEV BIOL LAB LOUVAIN BELGIUM
Titolo Testata:
European journal of biochemistry
fascicolo: 1, volume: 232, anno: 1995,
pagine: 47 - 53
SICI:
0014-2956(1995)232:1<47:ILASOI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
II IGF-II; FACTOR (IGF)-BINDING PROTEIN; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; HUMAN RHABDOMYOSARCOMA; CARCINOMA CELLS; RETINOIC ACID; RECEPTOR; ANTIESTROGENS; LINES;
Keywords:
INSULIN-LIKE-GROWTH-FACTOR-BINDING PROTEIN; MCF-7 CELLS; HUMAN BREAST CANCER; ESTROGEN; ANTIESTROGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
V. Dubois et al., "INTRACELLULAR LEVELS AND SECRETION OF INSULIN-LIKE-GROWTH-FACTOR-BINDING PROTEINS IN MCF-7 6, MCF-7/AZ AND MDA-MB-231 BREAST-CANCER CELLS -DIFFERENTIAL MODULATION BY ESTROGENS IN SERUM-FREE MEDIUM/", European journal of biochemistry, 232(1), 1995, pp. 47-53

Abstract

The synthesis and secretion of insulin-like growth factor binding proteins (IGFBPs) were studied in MDA-MB-231 (estrogen-receptor-negative), MCF-7/6 (estrogen-receptor-positive, invasive) and in MCF-7/AZ (estrogen-receptor-positive, non-invasive) human breast carcinoma cell lines. Cells were grown or maintained in a chemically defined medium. Under these conditions, we found different patterns of IGFBPs in the threecell types. MDA-MB-231 cells secrete most of the IGFBPs they produce whereas MCF-7/6 and MCF-7/AZ cells maintain a high intracellular level. In MDA-MB-231 cells, the major IGFBP is IGFBP-4 which is the minor form in MCF-7/6 and MCF-7/AZ cells. IGFBP-2 and IGFBP-5 are predominantin MCF-7/6 cells while MCF-7/AZ cells produce far less IGFBPs and do not contain detectable amounts of 29-32-kDa forms (IGFBP-5). In MCF-7/6 cells, estradiol-17 beta specifically decreases both the intracellular content and secretion of IGFBP-2 and IGFBP-5. Estrogen regulation of IGFBPs cell content and secretion was found to be tamoxifen-resistant, and only slightly antagonized by ICI 182,780, a pure antiestrogen. The function of these regulations relative to the invasive phenotype and proliferation has now to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:17:43