Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A PHYSIOLOGICAL-ROLE FOR GABA(B) RECEPTORS AND THE EFFECTS OF BACLOFEN IN THE MAMMALIAN CENTRAL-NERVOUS-SYSTEM
Autore:
MISGELD U; BIJAK M; JAROLIMEK W;
Indirizzi:
UNIV HEIDELBERG,INST PHYSIOL 1,NEUENHEIMER FELD 326 D-69120 HEIDELBERG GERMANY POLISH ACAD SCI,INST PHARMACOL PL-31343 KRAKOW POLAND
Titolo Testata:
Progress in neurobiology
fascicolo: 4, volume: 46, anno: 1995,
pagine: 423 - 462
SICI:
0301-0082(1995)46:4<423:APFGRA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; INHIBITORY POSTSYNAPTIC POTENTIALS; GUINEA-PIG HIPPOCAMPUS; RAT SUBSTANTIA-NIGRA; LATERAL GENICULATE-NUCLEUS; CALCIUM-CHANNEL CURRENTS; LOCUS COERULEUS NEURONS; DORSAL RAPHE NEURONS; CA1 PYRAMIDAL CELLS; STRATUM-LACUNOSUM-MOLECULARE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
395
Recensione:
Indirizzi per estratti:
Citazione:
U. Misgeld et al., "A PHYSIOLOGICAL-ROLE FOR GABA(B) RECEPTORS AND THE EFFECTS OF BACLOFEN IN THE MAMMALIAN CENTRAL-NERVOUS-SYSTEM", Progress in neurobiology, 46(4), 1995, pp. 423-462

Abstract

The inhibitory neurotransmitter GABA acts in the mammalian brain through two different receptor classes: GABA(A) and GABA(B) receptors. GABA(B) receptors differ fundamentally from GABA(A) receptors in that they require a G-protein. GABA(B) receptors are located pre- and/or post-synaptically, and are coupled to various K+ and Ca2+ channels presumably through both a membrane delimited pathway and a pathway involving second messengers. Baclofen, a selective GABA(B) receptor agonist, as well as GABA itself have pre- and post-synaptic effects. Pre-synaptic effects comprise the reduction of the release of excitatory and inhibitory transmitters. GABAergic receptors on GABAergic terminals may regulate GABA release, however, in most instances spontaneous inhibitory synaptic activity is not modulated by endogenous GABA. Post-synaptic GABA(B) receptor-mediated inhibition is likely to occur through a membrane delimited pathway activating K+ channels, while baclofen, in some neurons, may activate K+ channels through a second messenger pathway involving arachidonic acid. Some, but not all GABA(B) receptor-gated K+ channels have the typical properties of those G-protein-activated K+ channels which are also gated by other endogenous ligands of the brain. New, high affinity GABA(B) antagonists are now available, and some pharmacological evidence points to a receptor heterogeneity. The pharmacological distinction of receptor subtypes, however, has to await final support from a characterization of the molecular stucture. The functional importance of post-synaptic GABA(B) receptors is highlighted by a segregation of GABA(A) and GABA(B) synapses in the mammalian brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:49:14