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Titolo:
DIFFERENTIAL REGULATION OF SOLUBLE EPOXIDE HYDROLASE BY CLOFIBRATE AND SEXUAL HORMONES IN THE LIVER AND KIDNEYS OF MICE
Autore:
PINOT F; GRANT DF; SPEAROW JL; PARKER AG; HAMMOCK BD;
Indirizzi:
UNIV CALIF DAVIS,DEPT ENTOMOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT ENTOMOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT ENVIRONM TOXICOL DAVIS CA 95616 UNIV CALIF DAVIS,NEUROBIOL PHYSIOL & BEHAV SECT DAVIS CA 95616
Titolo Testata:
Biochemical pharmacology
fascicolo: 4, volume: 50, anno: 1995,
pagine: 501 - 508
SICI:
0006-2952(1995)50:4<501:DROSEH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXISOMAL BETA-OXIDATION; ACYL-COA OXIDASE; GLUTATHIONE S-TRANSFERASE; PERFLUORO-OCTANOIC ACID; RAT-LIVER; ACTIVATED RECEPTOR; CATALYTIC MECHANISM; FATTY ESTERS; PROLIFERATORS; EXPRESSION;
Keywords:
SOLUBLE EPOXIDE HYDROLASE; REGULATION; CLOFIBRATE; HORMONES; INDUCTION; PEROXISOME; PROLIFERATORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
F. Pinot et al., "DIFFERENTIAL REGULATION OF SOLUBLE EPOXIDE HYDROLASE BY CLOFIBRATE AND SEXUAL HORMONES IN THE LIVER AND KIDNEYS OF MICE", Biochemical pharmacology, 50(4), 1995, pp. 501-508

Abstract

Soluble epoxide hydrolase (sEH) activity was measured in the liver and kidneys of male, female, and castrated male mice in order to evaluate sex- and tissue-specific differences in enzyme expression. sEH activity was found to be higher in liver than in kidneys. Activity increased with age in the liver of females, males and castrated males, but only in males did activity in the kidneys increase. There was greater activity in both the liver and kidneys of adult males than females. This sexual dimorphism was more pronounced in the kidneys (283% higher) than in the liver (55% higher). Castration of males led to a decrease in activity in both organs, but it had a greater effect on renal activity(67% decrease) than on hepatic activity (27% decrease). Treatment of castrated mice with testosterone led to an increase in sEH activity of400% in kidneys and 49% in liver compared with surgical controls. These results suggest differential regulation of sEH by testosterone in kidneys and liver. Ovariectomized female mice had renal and hepatic activities approximately 30% greater than control females. Feeding mice with the hypolipidemic drug clofibrate produced stronger induction of sEH in liver than in kidneys. Testosterone treatment, however, caused greater induction in kidneys than in liver of females and castrated males and had no effect in either kidneys or liver in males. When given together, the effects of these two compounds appeared to be additive inboth liver and kidneys. Results from western blot showed that the increase in sEH enzyme activity in kidneys is correlated with an increasein sEH protein. These results suggest that clofibrate and testosterone independently regulate sEH activity in vivo, and that kidneys and liver respond differently to clofibrate and testosterone.

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Documento generato il 21/09/20 alle ore 16:11:54