Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SPECT IMAGING OF DOPAMINE-RECEPTORS WITH [I-123] EPIDEPRIDE - CHARACTERIZATION OF UPTAKE IN THE HUMAN BRAIN
Autore:
KORNHUBER J; BRUCKE T; ANGELBERGER P; ASENBAUM S; PODREKA I;
Indirizzi:
UNIV VIENNA,NEUROL KLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,NEUROL KLIN A-1090 VIENNA AUSTRIA UNIV VIENNA,NUCL MED CLIN A-1090 VIENNA AUSTRIA UNIV WURZBURG,DEPT PSYCHIAT W-8700 WURZBURG GERMANY FORSCHUNGSZENTRUM SEIBERSDORF SEIBERSDORF AUSTRIA
Titolo Testata:
Journal of neural transmission
fascicolo: 1-3, volume: 101, anno: 1995,
pagine: 95 - 103
SICI:
0300-9564(1995)101:1-3<95:SIODW[>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; I-125 EPIDEPRIDE; INVITRO BINDING; RAT-BRAIN; INVIVO; PET; RADIOLIGANDS; LIGAND; SCHIZOPHRENIA; TRANSPORTERS;
Keywords:
DOPAMINE; D-2 RECEPTOR; SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY (SPECT); EPIDEPRIDE; HUNTINGTONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J. Kornhuber et al., "SPECT IMAGING OF DOPAMINE-RECEPTORS WITH [I-123] EPIDEPRIDE - CHARACTERIZATION OF UPTAKE IN THE HUMAN BRAIN", Journal of neural transmission, 101(1-3), 1995, pp. 95-103

Abstract

[I-123]Epidepride is a new ligand for single photon emission computerized tomography (SPECT) that specifically labels D-2-like dopamine receptors with very high affinity. Here, we report on the regional kinetic uptake of [I-123]epidepride in the brain of 4 normal volunteers and 3 patients with choreatic movement disorders. In healthy subjects striatal activity peaked at 2.5 hours after injection of the tracer and decreased slowly thereafter. There were no significant differences between left and right brain hemispheres. Activity above background was also measurable in areas corresponding to the thalamus, temporal cortex and frontal cortex. The striatal to cerebellar ratio was about 14 after2.5 hours and this ratio steadily increased with time. The striatal to cerebellar ratio was clearly reduced in all 3 patients with choreatic movement disorders (from about 14 in control subjects after 2.5 hours to about 7 in choreatic patients). [I-123]Epidepride may be a usefulSPECT ligand for studying D-2 receptors in the living human brain because of its high target to background ratio, its high affinity and thepossibility to investigate extrastriatal D-2 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:05:40