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Titolo:
CLONING AND EXPRESSION OF A GENE ENCODING A T-CELL REACTIVE PROTEIN FROM COCCIDIOIDES-IMMITIS - HOMOLOGY TO 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE AND THE MAMMALIAN F-ANTIGEN
Autore:
WYCKOFF EE; PISHKO EJ; KIRKLAND TN; COLE GT;
Indirizzi:
UNIV TEXAS,DEPT BOT AUSTIN TX 78713 UNIV TEXAS,DEPT BOT AUSTIN TX 78713 UNIV CALIF SAN DIEGO,VET AFFAIRS MED CTR,DEPT PATHOL SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,VET AFFAIRS MED CTR,DEPT MED SAN DIEGO CA 92161
Titolo Testata:
Gene
fascicolo: 1, volume: 161, anno: 1995,
pagine: 107 - 111
SICI:
0378-1119(1995)161:1<107:CAEOAG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCES; IDENTIFICATION; DNA;
Keywords:
FUNGUS; PATHOGEN; IMMUNITY; PIGMENT FORMATION; GENOMIC CDNA SEQUENCES; PROTEIN HOMOLOGY; TRANSCRIPTION INITIATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
E.E. Wyckoff et al., "CLONING AND EXPRESSION OF A GENE ENCODING A T-CELL REACTIVE PROTEIN FROM COCCIDIOIDES-IMMITIS - HOMOLOGY TO 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE AND THE MAMMALIAN F-ANTIGEN", Gene, 161(1), 1995, pp. 107-111

Abstract

The gene which encodes a previously described T-cell reactive protein(TCRP) of the human fungal pathogen Coccidioides immitis (Ci) was cloned and sequenced. Both the genomic and cDNA sequences were determined. The transcription start point was confirmed. The tcrP gene has threeintrons and a 1197-bp ORF which translates to a 399-amino-acid (aa) protein (45.2 kDa). The predicted protein has approx. 50% aa sequence identity and 70% similarity to mammalian 4-hydroxyphenylpyruvate dioxygenase (HPPD) proteins and mammalian F-antigens. Expression of the Ci trcP in Escherichia coli resulted in production of a deep brown pigment, consistent with E. coli expression of the bacterial HPPD homolog from Shewanella colwelliana. The TCRP is likely the Ci form of HPPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/08/18 alle ore 08:31:09