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Titolo:
AGE-RELATED-CHANGES IN PLASMA-CATECHOLAMINE AND GLUCOSE RESPONSES OF F344 RATS TO A SINGLE FOOTSHOCK AS USED IN INHIBITORY AVOIDANCE TRAINING
Autore:
MABRY TR; GOLD PE; MCCARTY R;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,102 GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
Neurobiology of learning and memory
fascicolo: 2, volume: 64, anno: 1995,
pagine: 146 - 155
SICI:
1074-7427(1995)64:2<146:AIPAGR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-ADRENAL MEDULLARY; BLOOD-BRAIN-BARRIER; MEMORY STORAGE; ELDERLY HUMANS; SPONTANEOUS-ALTERNATION; EPINEPHRINE INJECTIONS; ADENYLATE-CYCLASE; FISCHER-344 RATS; SENILE DEMENTIA; SPATIAL MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
T.R. Mabry et al., "AGE-RELATED-CHANGES IN PLASMA-CATECHOLAMINE AND GLUCOSE RESPONSES OF F344 RATS TO A SINGLE FOOTSHOCK AS USED IN INHIBITORY AVOIDANCE TRAINING", Neurobiology of learning and memory, 64(2), 1995, pp. 146-155

Abstract

Young adult (3 months) and aged (22 months) Fischer 344 male rats were prepared with chronic tail artery catheters. Two days after surgery,rats were transferred to a test chamber and exposed to a single footshock (0, 0.25, 0.50, or 1.0 mA for 1 s). Blood samples were obtained from each rat under basal conditions and at timed intervals after exposure to footshock. Basal plasma levels of norepinephrine (NE) and epinephrine (EPI) were similar for 3- and 22-month-old rats. In contrast, plasma glucose (GLU) levels were significantly lower in aged rats compared to young adults. Increments in plasma levels of EPI were greater in aged rats compared to young adult controls following transfer of rats to the test chamber. In addition, aged rats had potentiated plasma EPI responses to footshock. Finally, aged rats had greater plasma levels of both catecholamines up to 5 min after a single training footshockcompared to young adult controls. However, the increased responsiveness of EPI in aged rats was not accompanied by proportionate increases in plasma GLU levels, i.e., the EPI-GLU relationship was uncoupled in aged rats. These findings point to dramatic differences between young adult and aged rats in their plasma EPI responses to inhibitory avoidance training. Age-related increases in EPI secreted from the adrenal medulla, together with decreased blood GLU responses, may contribute inpart to age-related deficits in memory modulatory processes. (C) 1995Academic Press, Inc.

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Documento generato il 08/07/20 alle ore 08:01:58