Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITORS OF CAMP-DEPENDENT PROTEIN-KINASE IMPAIR LONG-TERM-MEMORY FORMATION IN DAY-OLD CHICKS
Autore:
ZHAO WQ; POLYA GM; WANG BH; GIBBS ME; SEDMAN GL; NG KT;
Indirizzi:
LA TROBE UNIV,SCH PSYCHOL BUNDOORA VIC 3083 AUSTRALIA LA TROBE UNIV,SCH BIOCHEM BUNDOORA VIC 3083 AUSTRALIA LA TROBE UNIV,SCH CHEM BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Neurobiology of learning and memory
fascicolo: 2, volume: 64, anno: 1995,
pagine: 106 - 118
SICI:
1074-7427(1995)64:2<106:IOCPIL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL CA1 NEURONS; LIGHT CHAIN KINASE; II MUTANT MICE; CYCLIC-AMP; PASSIVE-AVOIDANCE; BEHAVIORAL SENSITIZATION; SIGNAL TRANSDUCTION; SYNAPTIC PLASTICITY; CATALYTIC SUBUNIT; RAT HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
W.Q. Zhao et al., "INHIBITORS OF CAMP-DEPENDENT PROTEIN-KINASE IMPAIR LONG-TERM-MEMORY FORMATION IN DAY-OLD CHICKS", Neurobiology of learning and memory, 64(2), 1995, pp. 106-118

Abstract

There is substantial evidence that protein kinases, through the phosphorylation of substrate proteins, play a significant role in information processing in the brain, including processes underlying memory formation. Inhibition of the activity of the cyclic-adenosine monophosphate-dependent protein kinase A by the highly specific inhibitor, halofantrine, resulted in impairment of memory formation in day-old chicks trained on a single-trial passive avoidance task. A dose of 9.6 ng/chickhalofantrine induced amnesia at the beginning of a protein synthesis-dependent long-term memory stage, the last of three stages of memory postulated to underly memory formation in the chick following passive avoidance learning. The concentration of halofantrine required for 50% inhibition of chick brain protein kinase A was found to be similar to that observed for bovine heart and rat liver. The amnestic effect of halofantrine is tentatively attributed to interference with de novo protein synthesis necessary for long-term memory consolidation. Neither anthraquinone nor the anthraquinone derivative anthraflavic acid, whichhave little effect on protein kinase A activity, affected memory retention. On the other hand, two other anthraquinone derivatives, chrysophanic acid and purpurin, which inhibit PKA activity, at doses of 0.25 and 0.5 ng/chick also yielded retention deficits. In these cases, however, retention losses occurred earlier than observed with halofantrine, at about 30 min post-training. The earlier effects of these inhibitors may be due to the additional inhibitory action of these compounds on protein kinase C activity, which has been demonstrated in previous studies to be implicated, possibly through phosphorylation of the GAP43phosphoprotein, in memory processing in the stage of memory immediately preceding the protein synthesis-dependent long-term stage. (C) 1995Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:46:44