Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE
Autore:
BABU YS; EALICK SE; BUGG CE; ERION MD; GUIDA WC; MONTGOMERY JA; SECRIST JA;
Indirizzi:
BIOCRYST PHARMACEUT INC,2190 PKWY LAKE DR BIRMINGHAM AL 35244 UNIV ALABAMA,CTR MACROMOLEC CRYSTALLOG BIRMINGHAM AL 35294 CIBA GEIGY CORP SUMMIT NJ 07901 SO RES INST BIRMINGHAM AL 35255
Titolo Testata:
Acta crystallographica. Section D, Biological crystallography
, volume: 51, anno: 1995,
parte:, 4
pagine: 529 - 535
SICI:
0907-4449(1995)51:<529:SDOIOP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
Y.S. Babu et al., "STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE", Acta crystallographica. Section D, Biological crystallography, 51, 1995, pp. 529-535

Abstract

Inhibitors of purine nucleoside phosphorylase may have therapeutic value in the treatment of T-cell proliferative diseases such as T-cell leukemia, in the suppression of host-versus-graft response in organ transplants, and in the treatment of T-cell-mediated autoimmune diseases. Competitive inhibitors of this enzyme have been designed using the three-dimensional structure of the enzyme determined by X-ray crystallography. This approach has resulted in the synthesis of the most potent and membrane-permeable inhibitors of purine nucleoside phosphorylase reported so far.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 13:58:39