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Titolo:
PHOSPHOLIPASE-C SIGNALING
Autore:
SMITH MR; LIU YL; RHEE SG; KUNG HF;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,BRMP,BIOCHEM PHYSIOL LAB FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,BRMP,BIOCHEM PHYSIOL LAB FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC,DYNCORP INC FREDERICK MD 21702 NHLBI,BIOCHEM LAB BETHESDA MD 20892
Titolo Testata:
Zoological studies
fascicolo: 3, volume: 34, anno: 1995,
pagine: 141 - 148
SICI:
1021-5506(1995)34:3<141:PS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE BRAIN; MONOCLONAL-ANTIBODIES; COMPLETE CDNA; SH2 DOMAIN; SEQUENCE; GROWTH; BINDING; PROTEIN; SRC; PHOSPHORYLATION;
Keywords:
PHOSPHOLIPASE C SIGNAL TRANSDUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Smith et al., "PHOSPHOLIPASE-C SIGNALING", Zoological studies, 34(3), 1995, pp. 141-148

Abstract

Recent experimental evidence indicate that phospholipids also play critical roles as mediators in cell activation and signal transduction. Phospholipases are the key enzymes that regulate Various signalling pathways. Inositol phospholipid-specific phospholipase C (PLC) catalyzesthe hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), to generate inositol triphosphate (IP3) and diacylglycerol (DAG) in response to several receptor-binding growth/differentiation factors, hormones, and neurotransmitters. The hydrolysis products serve as intracellular second messenger molecules which amplify the initial signalling events leading to cellular calcium mobilization by IP3 and protein kinase C (PKC) activation by DAG. In this article, we address two aspects to PLC signalling: 1. characterization, purification and molecular cloning of PLC isozymes; and 2. mitogenic and catalytic activities of PLC isozymes. In addition to reviewing published data on PLC signalling, we have included new data that examine the mitogenic activity of the PLC isozymes. PLC-beta and PLC-gamma induce DNA synthesis after microinjection into quiescent NIH/3T3 cells, while PLC-delta does not exhibit this activity. Monoclonal antibodies to PLC-gamma were shown to block serum-stimulated growth of NIH/3T3 cells and several oncogenes transformed NIH/3T3 cells (fes, src, ras and mos), yet Raf transformed cells were not inhibited by antibody injection. Thus, PLC-gamma signalling is required for serum- and (fes, src, ras and mps) oncogene-induced proliferation of fibroblasts.

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Documento generato il 10/04/20 alle ore 01:53:09