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Titolo:
EFFECTS OF DIET AND METFORMIN ADMINISTRATION ON SEX HORMONE-BINDING GLOBULIN, ANDROGENS, AND INSULIN IN HIRSUTE AND OBESE WOMEN
Autore:
CRAVE JC; FIMBEL S; LEJEUNE H; CUGNARDEY N; DECHAUD H; PUGEAT M;
Indirizzi:
HOP ANTIQUAILLE,CLIN ENDOCRINOL LAB,HOSPICES CIVILS LYON,1 RUE ANTIQUAILLE F-69321 LYON 05 FRANCE HOP ANTIQUAILLE,CENT BIOCHIM LAB F-69321 LYON 05 FRANCE HOP DEBROUSSE,INSERM,U329 LYON FRANCE
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 7, volume: 80, anno: 1995,
pagine: 2057 - 2062
SICI:
0021-972X(1995)80:7<2057:EODAMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC-OVARY-SYNDROME; STEROID-BINDING; CELL FUNCTION; PLASMA-LEVELS; TESTOSTERONE; PROTEIN; DEHYDROEPIANDROSTERONE; HYPERANDROGENISM; SENSITIVITY; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Crave et al., "EFFECTS OF DIET AND METFORMIN ADMINISTRATION ON SEX HORMONE-BINDING GLOBULIN, ANDROGENS, AND INSULIN IN HIRSUTE AND OBESE WOMEN", The Journal of clinical endocrinology and metabolism, 80(7), 1995, pp. 2057-2062

Abstract

Evidence suggests that hyperinsulinemic insulin resistance may increase serum levels of ovarian androgens and reduce sex hormone-binding globulin (SHBG) levels in humans. The present study was conducted to assess the effect of administration of the biguanide metformin, a drug commonly used in the treatment of diabetes mellitus, on androgen and insulin levels in 24 hirsute patients. The patients selected for the study were obese, with a body mass index higher than 25 kg/m(2) and high fasting insulin (>90 pmol/L) and low SHBG levels (<30 nmol/L). All patients were given a low calorie diet (1500 Cal/day) and randomized for either metformin administration at a dose of 850 mg or a placebo, twicedaily for 4 months, in a double blind study. In the placebo group, diet resulted in a significant decrease in body mass index (30.8 +/- 1.0vs. 32.7 +/- 1.5 kg/m(2); P < 0.0001), fasting insulin (127 +/- 11 vs. 156 +/- 14 pmol/L: P < 0.01), non-SHBG-bound testosterone (0.19 +/- 0.02 vs. 0.28 +/- 0.03 nmol/L; P 0.02), androstenedione (5.8 +/- 0.5 vs. 9.0 +/- 1.1 nmol/L; P < 0.03), and 3 alpha-diolglucuronide (8.6 +/-1.1 vs. 11.7 +/- 1.9; P < 0.005) plasma concentrations and a significant increase in the glucose/insulin ratio (0.047 +/- 0.005 vs. 0.035 +/- 0.003; P < 0.001) and plasma concentrations of SHBG (26.0 +/- 3.3 vs. 19.1 +/- 1.9 nmol/L; P < 0.001) and dehydroepiandrosterone sulfate (8.7 +/- 1.5 vs. 8.4 +/- 1.3; P < 0.05). Beneficial effects of diet were not significantly different in the patients who were given metformin instead of placebo. These results confirm that weight loss induced by a low calorie diet is effective in improving hyperinsulinemia and hyperandrogenism in obese and hirsute women. With our study design, metformin administration had no additional benefit over the effect of diet.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:48:31