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Titolo:
PERCUTANEOUS PENETRATION AND METABOLISM OF SALICYLIC-ACID DERIVATIVESACROSS HAIRLESS MOUSE SKIN IN-DIFFUSION CELL IN-VITRO
Autore:
HIGO N; SATO S; IRIE T; UEKAMA K;
Indirizzi:
KUMAMOTO UNIV,FAC PHARMACEUT SCI,5-1 OE HONMACHI KUMAMOTO 862 JAPAN KUMAMOTO UNIV,FAC PHARMACEUT SCI KUMAMOTO 862 JAPAN HISAMITSU PHARMACEUT CO LTD,TSUKUBA LABS TSUKUBA IBARAKI 305 JAPAN
Titolo Testata:
STP pharma sciences
fascicolo: 4, volume: 5, anno: 1995,
pagine: 302 - 308
SICI:
1157-1489(1995)5:4<302:PPAMOS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO; NITROGLYCERIN; PERMEABILITY; ABSORPTION; KINETICS;
Keywords:
SALICYLATES; L-MENTHOL; PERCUTANEOUS PENETRATION; CUTANEOUS METABOLISM; STRUCTURE ACTIVITY CORRELATION; SATURATION OF ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
N. Higo et al., "PERCUTANEOUS PENETRATION AND METABOLISM OF SALICYLIC-ACID DERIVATIVESACROSS HAIRLESS MOUSE SKIN IN-DIFFUSION CELL IN-VITRO", STP pharma sciences, 5(4), 1995, pp. 302-308

Abstract

Percutaneous penetration and metabolism of seven salicylic acid derivatives were studied using hairless mouse skin in a flow-through type diffusion cell in vitro. The percutaneous penetration of the salicylates showed a parabolic dependence on their n-octanol/water partition coefficient This suggests a shift in the rate-controlling membrane from the stratum corneum to the epidermis for the most lipophilic compound, n-butyl salicylate. For the other salicylates studied the parabolic dependence can be explained solely by their solubilities in the stratum corneum. Of the salicylates tested, the least permeable n-butyl salicylate was metabolized the most during the passage through the skin. Alternatively, higher levels of permeation and consequently, higher concentrations of the salicylates in the skin saturated the metabolic process that is active in the skin. The pretreatment of the skin with 1-menthol inhibited the cutaneous metabolism of the salicylates without anyflux enhancement, probably through the competitive inhibition of the enzymes and not because of the enzyme saturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:00:39