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Titolo:
MAGNETIC-RESONANCE SPECTROSCOPY IN MIGRAINE
Autore:
MONTAGNA P;
Indirizzi:
UNIV BOLOGNA,INST CLIN NEUROL,NEUROL CLIN,VIA UGO FOSCOLO 7 I-40123 BOLOGNA ITALY
Titolo Testata:
Cephalalgia
fascicolo: 4, volume: 15, anno: 1995,
pagine: 323 - 327
SICI:
0333-1024(1995)15:4<323:MSIM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN ENERGY-METABOLISM; HUMAN SKELETAL-MUSCLE; INVIVO P-31; MITOCHONDRIAL CYTOPATHIES; OXIDATIVE-METABOLISM; PHOSPHATE-TRANSPORT; PH; PHOSPHOCREATINE; H-1; NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
P. Montagna, "MAGNETIC-RESONANCE SPECTROSCOPY IN MIGRAINE", Cephalalgia, 15(4), 1995, pp. 323-327

Abstract

31-phosphorus Magnetic Resonance Spectroscopy (MRS) is a technique developed for the non-invasive study of energy metabolism in living subjects. It determines the concentrations of high and low energy phosphates in resting and activated conditions, and of intracellular pH. 31P-MRS has been applied to the study of migraine, both during and in between attacks. Intracellular brain pH remains unchanged during the migraine attack, suggesting that ischemia does not play a relevant role in the origin of the neurological signs. During and in-between attacks, migraineurs display abnormalities in energy metabolism of brain and muscle, consisting of reduced levels of phosphocreatine, reduced cellular-free energy and increased rate of ATP biosynthesis. We suggest that these abnormalities in energy metabolism predispose migraineurs to develop an attack under conditions of increased brain energy demand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:06:55