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Titolo:
PHOTOCHEMICAL DECOMPOSITION OF MIDAZOLAM .4. STUDY OF PH-DEPENDENT STABILITY BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
Autore:
ANDERSIN R; TAMMILEHTO S;
Indirizzi:
HELSINKI UNIV,DEPT PHARM,DIV PHARMACEUT CHEM,POB 15 SF-00014 HELSINKIFINLAND
Titolo Testata:
International journal of pharmaceutics
fascicolo: 2, volume: 123, anno: 1995,
pagine: 229 - 235
SICI:
0378-5173(1995)123:2<229:PDOM.S>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROCHLORIDE; FORMULATIONS;
Keywords:
MIDAZOLAM; STABILITY; PHOTOCHEMICAL DECOMPOSITION; HPLC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R. Andersin e S. Tammilehto, "PHOTOCHEMICAL DECOMPOSITION OF MIDAZOLAM .4. STUDY OF PH-DEPENDENT STABILITY BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY", International journal of pharmaceutics, 123(2), 1995, pp. 229-235

Abstract

A high-performance liquid chromatographic method was developed for the quantitation of midazolam in aqueous solutions exposed to light. Midazolam was separated from its main decomposition products on a Lichrosorb RP-18 column with a mobile phase consisting of methanol and 50 mM phosphoric acid with triethylamine, and the pH of the aqueous component adjusted to 3.5 with sodium hydroxide. The method showed good intra-day and inter-day precision and accuracy (RSD and RE < 2.5%). The quantitative assay of midazolam in photodecomposed citrate buffer solutions indicated the decomposition to be dependent on the pH of the aqueoussolution; the rate of decomposition was lowest at very acidic pH and faster when the pH of the solutions was increased.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 21:21:35