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Titolo:
CHEMOKINES IN BRONCHOALVEOLAR LAVAGE FLUID IN SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS
Autore:
SUGIYAMA Y; KASAHARA T; MUKAIDA N; MATSUSHIMA K; KITAMURA S;
Indirizzi:
JICHI MED SCH,DEPT PULM MED MINAMI KAWACHI TOCHIGI 32904 JAPAN JICHI MED SCH,DEPT MED BIOL MINAMI KAWACHI TOCHIGI 32904 JAPAN JICHI MED SCH,DEPT MICROBIOL & PARASITOL MINAMI KAWACHI TOCHIGI 32904JAPAN KANAZAWA UNIV,CANC RES INST,DEPT PHARMACOL KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
The European respiratory journal
fascicolo: 7, volume: 8, anno: 1995,
pagine: 1084 - 1090
SICI:
0903-1936(1995)8:7<1084:CIBLFI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC FACTOR; IDIOPATHIC PULMONARY FIBROSIS; BLOOD MONONUCLEAR LEUKOCYTES; ACTIVATING FACTOR MCAF; GENE-EXPRESSION; MESSENGER-RNA; ALVEOLAR MACROPHAGES; INTERLEUKIN-8 GENE; TNF-ALPHA; CELL-LINE;
Keywords:
BRONCHOALVEOLAR LAVAGE; HYPERSENSITIVITY PNEUMONITIS; INTERLEUKIN-8; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. Sugiyama et al., "CHEMOKINES IN BRONCHOALVEOLAR LAVAGE FLUID IN SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS", The European respiratory journal, 8(7), 1995, pp. 1084-1090

Abstract

Hypersensitivity pneumonitis (HP) is a granulomatous interstitial lung disease caused by the inhalation of a variety of antigens and is characterized by a dramatic accumulation of inflammatory cells, includingneutrophils, lymphocytes and macrophages, in the lung, The mechanismsimplicated in the inflammatory cell recruitment observed in hypersensitivity pneumonitis are unknown. We examined the concentrations of twoimportant chemokines; interleukin-8 (IL-8) and monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF), in the bronchoalveolar lavage fluid (BALF) of patients with summer-type hypersensitivity pneumonitis (n=8), and compared them with those in patients with sarcoidosis (n=13) and with controls (n=8). In the BALF of slammer-type hypersensitivity pneumonitis, the levels both of IL-8 and MCP-1 were significantly increased compared with levels measured in control subjects, On the other hand, compared to the control value, the MCP-1 level in the BALF of the sarcoidosis patients was significantly increased, but IL-8 was only slightly and nonsignificantly increased. Since IL-8 is a chemoattractant for neutrophils and T-lymphocytes,whereas MCP-1 acts mainly on monocytes/macrophages, our findings may indicate that these two chemokines participate in the cellular accumulation observed in hypersensitivity pneumonitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:24:59