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Titolo:
UNDERCARBOXYLATED OSTEOCALCIN AND DEVELOPMENT OF A METHOD TO DETERMINE VITAMIN-K STATUS
Autore:
SOKOLL LJ; OBRIEN ME; CAMILO ME; SADOWSKI JA;
Indirizzi:
JOHNS HOPKINS MED INST,DEPT PATHOL,DIV CLIN CHEM,600 N WOLFE ST,MEYERB-125 BALTIMORE MD 21287 TUFTS UNIV,JEAN MAYER USDA HUMAN NUTR RES CTR AGING BOSTON MA 02111
Titolo Testata:
Clinical chemistry
fascicolo: 8, volume: 41, anno: 1995,
parte:, 1
pagine: 1121 - 1128
SICI:
0009-9147(1995)41:8<1121:UOADOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-CARBOXYGLUTAMIC ACID; BONE GLA-PROTEIN; URINARY CALCIUM EXCRETION; CIRCULATING OSTEOCALCIN; ORAL ANTICOAGULANT; PLASMA OSTEOCALCIN; SERUM OSTEOCALCIN; ELDERLY WOMEN; RADIOIMMUNOASSAY; ANTIBODY;
Keywords:
RADIOIMMUNOASSAY; ANTICOAGULANTS; NUTRITIONAL STATUS; WARFARIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
L.J. Sokoll et al., "UNDERCARBOXYLATED OSTEOCALCIN AND DEVELOPMENT OF A METHOD TO DETERMINE VITAMIN-K STATUS", Clinical chemistry, 41(8), 1995, pp. 1121-1128

Abstract

We developed a RIA involving a polyclonal antibody against bovine osteocalcin, which has a carboxy-terminal epitope. Although the antibody recognizes both native and descarboxy osteocalcin, the two forms of osteocalcin were differentiated by adsorption to barium sulfate, taking advantage of the calcium-binding properties of the vitamin K-dependentgla domain. To test the clinical application of undercarboxylated osteocalcin, we examined the effect of minidose warfarin on this measure in nine healthy subjects, ages 60 to 80 years. The percentage of undercarboxylated osteocalcin increased by 170% +/- 36% (mean +/- SE) after7 days of treatment with warfarin, 1 mg/day. The effectiveness of undercarboxylated osteocalcin as a sensitive measure of vitamin K nutritional status was further established when concentrations dropped to 17%+/- 14% below baseline with 2 days of repletion with vitamin K-1, 5 mg/day, during which prothrombin times did not leave the normal range.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:03:24