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Titolo:
ENDOGENOUS SEROTONIN RELEASE FROM THE DOPAMINE-DEFICIENT STRIATUM OF THE WEAVER MUTANT MOUSE
Autore:
STOTZPOTTER EH; GHETTI B; SIMON JR;
Indirizzi:
INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT PSYCHIAT,791 UNION DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT PSYCHIAT INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PATHOL & LAB MED NEUROPATHOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,PROGRAM MED NEUROBIOL INDIANAPOLIS IN 46202
Titolo Testata:
Neurochemical research
fascicolo: 7, volume: 20, anno: 1995,
pagine: 821 - 826
SICI:
0364-3190(1995)20:7<821:ESRFTD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAINING INNERVATION; FIBER VULNERABILITY; MESOSTRIATAL SYSTEM; D-FENFLURAMINE; MECHANISMS; MUTATION; PATTERNS; CELL; MICE; GENE;
Keywords:
SEROTONIN; RELEASE; WEAVER; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.H. Stotzpotter et al., "ENDOGENOUS SEROTONIN RELEASE FROM THE DOPAMINE-DEFICIENT STRIATUM OF THE WEAVER MUTANT MOUSE", Neurochemical research, 20(7), 1995, pp. 821-826

Abstract

In addition to an altered dopaminergic input, the striatum of the weaver mutant mouse (wv/wv) has increased serotonin tissue content and uptake compared to the wild-type mouse (+/+). To gain information regarding the functional status of serotonergic inputs to the wv/wv striatum, endogenous serotonin release from wv/wv and +/+ striatum was measured under basal conditions as well as in the presence of fenfluramine orelevated concentrations of potassium (K+). Fractional basal release of serotonin from the +/+ striatum was significantly greater than that from the wv/wv striatum. In the presence of K+, evoked release (stimulated release minus basal release) was greater from the +/+ striatum than from the wv/wv striatum. In the presence of fenfluramine, evoked serotonin release was greater from the wv/wv striatum compared to the +/ striatum. These data are consistent with the involvement of an additional transmitter(s) in modulating serotonin release to a greater extent in the wv/wv than the +/+ striatum. The data on fenfluramine-stimulated serotonin release suggest that the additional serotonin content found in the wv/wv striatum is in a releasable pool but that striatal serotonin release might be attenuated more in wv/wv than in +/+ mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 16:18:20