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Titolo:
INNATE RESISTANCE TO LETHAL MOUSEPOX IS GENETICALLY LINKED TO THE NK GENE-COMPLEX ON CHROMOSOME-6 AND CORRELATES WITH EARLY RESTRICTION OF VIRUS-REPLICATION BY CELLS WITH AN NK PHENOTYPE
Autore:
DELANO ML; BROWNSTEIN DG;
Indirizzi:
YALE UNIV,SCH MED,COMPARAT MED SECT,333 CEDAR ST NEW HAVEN CT 06510 YALE UNIV,SCH MED,COMPARAT MED SECT NEW HAVEN CT 06510
Titolo Testata:
Journal of virology
fascicolo: 9, volume: 69, anno: 1995,
pagine: 5875 - 5877
SICI:
0022-538X(1995)69:9<5875:IRTLMI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-ASIALO GM1; ECTROMELIA VIRUS; INDUCED MORTALITY; KILLER-CELLS; INFECTION; NKR-P1; MICE; IDENTIFICATION; MARKERS; CLONING;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Delano e D.G. Brownstein, "INNATE RESISTANCE TO LETHAL MOUSEPOX IS GENETICALLY LINKED TO THE NK GENE-COMPLEX ON CHROMOSOME-6 AND CORRELATES WITH EARLY RESTRICTION OF VIRUS-REPLICATION BY CELLS WITH AN NK PHENOTYPE", Journal of virology, 69(9), 1995, pp. 5875-5877

Abstract

Most inbred strains of mice, including DBA/2 (D2), are highly susceptible to the lethal effects of ectromelia virus, but C57B/6 (B6) mice are innately resistant, Resistance is controlled by multiple, unlinked,autosomal dominant genes. Of 101 male (B6 x D2)F-1 x D2 backcrossed (N2) mice, 18 died after ectromelia virus challenge and all were homozygous for the D2 allele at the proline-rich protein (Prp) locus on distal chromosome 6 (P < 0.001). This association was suggested by the patterns of susceptibility to lethal mousepox in recombinant inbred strains derived from B6 and D2 mice (D, G. Brownstein, P, N, Bhatt, L. Gras, and R. O, Jacoby, J, Virol, 65:1946-1951, 1991), The association between the Prp locus and susceptibility to lethal mousepox also held forN2 male mice that were castrated as neonates, which increased the percentage that were susceptible to 40. Spleen virus titers were significantly augmented in B6 (Nk1.1(+)) mice depleted of asialo GM1(+) or NK1.1(+) cells; whereas spleen virus titers were unaffected in D2 (NK1.1(-)) mice depleted of asialo GM1(+) cells, These results suggest that agene or genes within the natural killer gene complex, adjacent to thePrp locus, determine strain variations in resistance to lethal ectromelia virus infection.

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Documento generato il 30/11/20 alle ore 10:07:17