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Titolo:
MONOCLONAL-ANTIBODIES SPECIFIC FOR EQUINE IGG SUB-ISOTYPES INCLUDING AN ANTIBODY WHICH RECOGNIZES B-LYMPHOCYTES
Autore:
LUNN DP; HOLMES MA; SCHRAM B; DUFFUS WPH;
Indirizzi:
UNIV WISCONSIN,SCH VET MED,DEPT MED SCI,2015 LINDEN DR W MADISON WI 53706
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 3-4, volume: 47, anno: 1995,
pagine: 239 - 251
SICI:
0165-2427(1995)47:3-4<239:MSFEIS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLUENZA-VIRUS; SURFACE IGM; SERUM; ANTIGENS; IMMUNOGLOBULINS; IDENTIFICATION; INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Lunn et al., "MONOCLONAL-ANTIBODIES SPECIFIC FOR EQUINE IGG SUB-ISOTYPES INCLUDING AN ANTIBODY WHICH RECOGNIZES B-LYMPHOCYTES", Veterinary immunology and immunopathology, 47(3-4), 1995, pp. 239-251

Abstract

Equine immunoglobulin G is currently classified as consisting of fivesub-isotypes: IgGa, b, and c, IgG(T), and IgG(B). The study of the role of these immunoglobulins in antigen-specific responses, and the examination of their functional properties would be greatly facilitated by the availability of monoclonal antibodies (Mabs) that distinguish between them. The production and characterization of two Mabs that recognize an IgG sub-isotype with the characteristics of IgG(ab) is described. The immunoglobulin identified by these Mabs had a heavy chain weight of 53 kDa, was of rapid cathodal electrophoretic mobility in immuno-electrophoretic analysis, and reacted only with anti-sera to IgG, andnot with anti-sera to IgG(T), IgA, or IgM in radial-immunodiffusion analysis. In addition, one of these two Mabs (CVS1) also recognized themajority of peripheral blood B lymphocytes in indirect immunofluorescent staining analysis, suggesting either that equine IgD may share a common antigenic epitope with an IgG sub-isotype, or that a large proportion of equine B lymphocytes may express an IgG sub-isotype on their surface.

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Documento generato il 26/09/20 alle ore 13:53:18